Predictive Factors of Hemorrhage After Thrombolysis in Patients With Acute Ischemic Stroke
Autor: | Yan-Jun Gao, Cheng-Bo Li, Hui-Xiao Fu, Jiang Zhu, Zheng Ma, Zhi-Jie Dou, Heng Liu, Fan Sun, Xiao-Jing Geng, Xiao-Xuan Zhang |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
medicine.medical_specialty acute ischemic stroke medicine.medical_treatment lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Hyperlipidemia Medicine caveolin-2 (Cav-2) hemorrhagic transformation (HT) Pathological lcsh:Neurology. Diseases of the nervous system Original Research Anamnesis business.industry biomarkers Atrial fibrillation Thrombolysis medicine.disease 030104 developmental biology Blood pressure Neurology caveolin-1 (Cav-1) Cardiology Neurology (clinical) business Plasminogen activator 030217 neurology & neurosurgery |
Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 11 (2020) |
ISSN: | 1664-2295 |
DOI: | 10.3389/fneur.2020.551157 |
Popis: | Background: Ischemic stroke has a poor prognosis and brings a ponderous burden on families and society. Hemorrhagic transformation (HT) after intravenous thrombolysis can increase the mortality of patients with ischemic stroke. Thus, finding new HT biomarkers to be applicable in clinical practice is of great importance. Methods: The related risk factors were recruited for analysis, including smoking, drinking, hyperlipidemia, diabetes, anamnesis, and pathological indicators. Moreover, the relationship between serum levels of caveolin-1, caveolin-2, and HT after rt-PA treatment were also studied. Results: We studied 306 patients with acute ischemic stroke treated with recombinant tissue type plasminogen activator (rt-PA) within 4.5 h of symptom onset. The results showed that Age ≥68 years, smoking, Atrial fibrillation, NIHSS score before thrombolysis ≥17, and systolic pressure 2 h after thrombolysis (mmHg) ≥149 increased the risks of HT after rt-PA administration. Remarkably, the concentration of caveolin-1 (ng/mL) ≤ 0.12 and caveolin-2 (ng/mL) ≤ 0.43 in serum increased the risks of HT after rt-PA administration. Conclusion: Knowledge on the risk factors associated with HT after rt-PA treatment may help develop treatment strategies and reduce the risk of HT. Caveolin-1 and caveolin-2 can be predictors of HT after rt-PA administration. These findings provide evidence for future further investigations aimed to validate these biomarkers. |
Databáze: | OpenAIRE |
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