Meta-analysis of randomized controlled trials on atrial fibrillation ablation in patients with heart failure with reduced ejection fraction
| Autor: | Yousef Darrat, Alok Saurav, Hussam Abuissa, Amjad Kabach, Toufik Mahfood Haddad, Abdulghani Saadi, Mohsin Salih, Aiman Smer, Claude S. Elayi, Raviteja R. Guddeti, Mohamed Ayan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Population Clinical Investigations Catheter ablation Comorbidity 030204 cardiovascular system & hematology Ventricular Function Left law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Risk Factors law Internal medicine Atrial Fibrillation medicine Humans 030212 general & internal medicine education Aged Randomized Controlled Trials as Topic Heart Failure education.field_of_study Ejection fraction business.industry Stroke Volume Atrial fibrillation General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Treatment Outcome Heart failure Catheter Ablation Cardiology Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents |
| Zdroj: | Clinical Cardiology. 41:1430-1438 |
| ISSN: | 0160-9289 |
| DOI: | 10.1002/clc.23068 |
| Popis: | BACKGROUND: The role of catheter ablation (CA) is increasingly recognized as a reasonable therapeutic option in patients with atrial fibrillation (AF) and heart failure (HF). HYPOTHESIS: We aimed to compare CA to medical therapy in AF patients with HF with reduced ejection fraction (HFrEF). METHODS: We searched the literature for randomized clinical trials comparing CA to medical therapy in this population. RESULTS: Six trials with a total of 775 patients were included. AF was persistent in 95% of patients with a mean duration of 18.5 ± 23 months prior enrollment. The mean age was 62.2 ± 7.8 years, mostly males (83%) with mean left ventricular ejection fraction (LVEF) of 31.2 ± 6.7%. Compared to medical therapy, CA has significantly improved LVEF by 5.9% (Mean difference [MD] 5.93, confidence interval [CI] 3.59‐8.27, P |
| Databáze: | OpenAIRE |
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