Sex Differences in Autism-Like Behavioral Phenotypes and Postsynaptic Receptors Expression in the Prefrontal Cortex of TERT Transgenic Mice
| Autor: | Hee Jin Kim, Judy Kyoungju Noh, Se Jin Jeon, Sung Min Yang, Ki Chan Kim, Ji-Woon Kim, Darine Froy N. Mabunga, Schley Valencia, Kyu Suk Cho, Geon Ho Bahn, Chang Soon Choi, Edson Luck Gonzales, Chan Young Shin, Pyeong Hwa Eun, Seol-Heui Han |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genetically modified mouse medicine.medical_specialty AMPA receptor Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Postsynaptic potential Internal medicine Drug Discovery Excitatory/Inhibitory imbalance medicine Autism spectrum disorder Prefrontal cortex Receptor Pharmacology TERT transgenic mice Sex difference medicine.disease Synapse 030104 developmental biology Endocrinology Molecular Medicine NMDA receptor Autism Original Article 030217 neurology & neurosurgery |
| Zdroj: | Biomolecules & Therapeutics |
| ISSN: | 1976-9148 2005-4483 |
| Popis: | Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female population. Using a validated animal model of ASD which is the telomerase reverse transcriptase overexpressing mice (TERT-tg), we conducted ASD-related behavioral assessments and protein expression experiments to mark the difference between male and females of this animal model. After statistically analyzing the results, we found significant effects of TERT overexpression in sociability, social novelty preference, anxiety, nest building, and electroseizure threshold in the males but not their female littermates. Along these differences are the male-specific increased expressions of postsynaptic proteins which are the NMDA and AMPA receptors in the prefrontal cortex. The vGluT1 presynaptic proteins, but not GAD, were upregulated in both sexes of TERT-tg mice, although it is more significantly pronounced in the male group. Here, we confirmed that the behavioral effect of TERT overexpression in mice was male-specific, suggesting that the aberration of this gene and its downstream pathways preferentially affect the functional development of the male brain, consistent with the male preponderance in ASD. |
| Databáze: | OpenAIRE |
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