Chronic oral arsenic intoxication as a possible aetiological factor in idiopathic portal hypertension (non-cirrhotic portal fibrosis) in India
| Autor: | P. N. Chhuttani, Rajarshi Chakravarti, S. K. Mitra, Debabrata Datta |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Pathology Nostrums Cirrhosis Adolescent India Arsenic poisoning chemistry.chemical_element Gastroenterology Arsenic Internal medicine Arsenic Poisoning Hypertension Portal medicine Humans Child business.industry Opium medicine.disease Collateral circulation Medicine Ayurvedic Liver chemistry Portal fibrosis Etiology Portal hypertension Female business Research Article medicine.drug |
| Zdroj: | Gut. 20:378-384 |
| ISSN: | 0017-5749 |
| Popis: | Estimates were made of the arsenic concentration in liver specimens from nine patients having idiopathic portal hypertension (IP), and in four livers these were found to be significantly higher than those in patients with cirrhosis and in control subjects. The splenovenogram revealed extensive portosystemic collateral circulation. Corrected sinusoidal pressure and blood flow studies showed higher levels in four patients than in normal subjects. Microscopic examination of liver tissues revealed periportal fibrosis. The higher hepatic arsenic levels that were found were due to the inadvertent drinking of water contaminated with arsenic, adulterated opium, and indigenous medicines. A history of opium intake was not forthcoming but two patients had drunk water contaminated with arsenic and two others had taken bhasams (Ayurvedic medicines prepared by repeated oxidation of ores). Though the aetiology of idiopathic portal hypertension is not known, it is possible that arsenic intake may be one of the factors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|