The effect of hydrogen sulphide on experimental cerebral vasospasm
| Autor: | M. Kemali Baykaner, İpek Işık Gönül, Ihsan Solaroglu, Hakan Emmez, Alp Özgün Börcek, Hayrunnisa Bolay Belen |
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| Přispěvatelé: | Solaroğlu, İhsan (ORCID 0000-0002-9472-1735 & YÖK ID 102059), Emmez, Hakan, Börcek, Alp Özgün, Gönül, İpek Işık, Bolay Belen, Hayrunnisa, Baykaner, Kemali, School of Medicine, Department of Neurosurgery |
| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Subarachnoid hemorrhage Vasodilator Agents Central nervous system Hydrogen sulphide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cerebral vasospasm Internal medicine medicine.artery medicine Basilar artery Animals Vasospasm Intracranial Hydrogen Sulfide cardiovascular diseases Neurotransmitter biology Medicine Neurosurgery business.industry Vasospasm Subarachnoid Hemorrhage equipment and supplies medicine.disease Cystathionine beta synthase Rats nervous system diseases 030104 developmental biology medicine.anatomical_structure chemistry Basilar Artery cardiovascular system Cardiology biology.protein Surgery sense organs Neurology (clinical) business Hydrogen sulfide 030217 neurology & neurosurgery |
| Zdroj: | Turkish Neurosurgery |
| ISSN: | 1019-5149 |
| DOI: | 10.5137/1019-5149.jtn.16101-15.1 |
| Popis: | AIM: Cerebral vasospasm is the primary cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Hydrogen Sulfide (H2S), a gaseous neurotransmitter, is produced in many tissues including the central nervous system (CNS). The vasodilatatory effect of H2S has been shown in the CNS; however, its role in cerebral vasospasm has not been investigated before. MATERIAL and METHODS: The rats were divided into 8 groups: control, SAH, sodium hydrosulphide (NaHS), propargylglycine (PPG), aminooxy acetic acid (AOAA), SAH+NaHS, SAH+PPG, and SAH+AOAA. After establishing experimental SAH, the basilar artery and brain stem were harvested at 24th hours. The diameter and wall thickness of basilar artery were measured. Production of H2S was assessed by showing the activity of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase enzymes (CSE). RESULTS: NaHS treatment significantly reduced vasospasm at 24 hours following SAH. This vasodilatatory effect was correlated with the CSE expression in basilar artery. CSE and CBS enzyme expressions were significantly lower in brain stem and basilar artery in PPG and AOAA-treated groups. PPG and AOAA treatments exerted a vasoconstrictive effect in the basilar artery. There were statistically significant differences between NaHS, PPG and AOAA groups, in terms of basilar artery lumina! diameter. CONCLUSION: H2S may have a therapeutic potential in the treatment of vasospasm with its vasodilatator activity. NA |
| Databáze: | OpenAIRE |
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