c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration
| Autor: | Clifford A. Lowell, Ilaria Iacobucci, Anna Baruzzi, Simona Soverini, Giovanni Martinelli, Giorgio Berton |
|---|---|
| Přispěvatelé: | Baruzzi A., Iacobucci I., Soverini S., Lowell C.A., Martinelli G., Berton G. |
| Rok vydání: | 2009 |
| Předmět: |
Proto-Oncogene Proteins c-hck
Neutrophils Macrophage Biophysics Signal transduction Biology Proto-Oncogene Proteins c-fyn Biochemistry Article Mice chemistry.chemical_compound Cell Movement Structural Biology Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Genetics Animals Humans Myeloid Cells Phosphorylation Proto-Oncogene Proteins c-abl cdc42 GTP-Binding Protein Tyrosine kinase neoplasms Molecular Biology Mice Knockout Phagocytes ABL MACROPHAGE TYROSINE KINASE CHEMOTAXIS SIGNAL TRANSDUCTION Kinase Chemotaxis Neutrophil Cell Polarity Tyrosine phosphorylation Cell Biology C-ABL SRC-FAMILY KINASES rac GTP-Binding Proteins Cell biology Rac GTP-Binding Proteins chemistry Cancer research |
| Zdroj: | FEBS Letters. 584:15-21 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2009.11.009 |
| Popis: | Cytoskeleton dynamics are regulated by Src-family tyrosine kinases (SFKs) and c-Abl. We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with β1 integrin-bound Hck or c-Fgr in murine macrophages. Studies with selective inhibitors and cells from SFK-deficient mice showed that c-Abl and SFK regulate migration and activation of the small GTPases Cdc42 and Rac in macrophages. Additionally, human neutrophil chemotactic activity was reduced by c-Abl inhibitors, and neutrophils from chronic myeloid leukaemia patients displayed an increased chemotactic ability. Hence, Src-family kinase and c-Abl cross-talk in the regulation of myeloid cell migration.Structured summaryMINT-7296608: Integrin beta-1 (uniprotkb:P09055) physically interacts (MI:0914) with Hck (uniprotkb:P08103), Abl (uniprotkb:P00520) and Fgr (uniprotkb:P14234) by anti bait coimmunoprecipitation (MI:0006) MINT-7296596: Integrin beta-1 (uniprotkb:P09055) physically interacts (MI:0914) with Fgr (uniprotkb:P14234) and Abl (uniprotkb:P00520) by anti bait coimmunoprecipitation (MI:0006) |
| Databáze: | OpenAIRE |
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