The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes

Autor:	R.M. Roop, Philip H. Elzer, R W Phillips, Gregory T. Robertson
Rok vydání:	1996
Předmět:	Phagocyte Neutrophils medicine.medical_treatment Immunology Mutant Virulence Brucella abortus Brucellaceae Microbiology complex mixtures Brucellosis Gene product Mice Bacterial Proteins Heat shock protein medicine Macrophage Animals Cells Cultured Heat-Shock Proteins Mice Inbred BALB C Phagocytes Protease biology Macrophages Serine Endopeptidases biology.organism_classification bacterial infections and mycoses Virology Infectious Diseases medicine.anatomical_structure Mutation bacteria Parasitology Periplasmic Proteins Research Article
Zdroj:	Infection and immunity. 64(11)
ISSN:	0019-9567
Popis:	Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing by cultured murine neutrophils and macrophages and significant attenuation during the early stages of infection in the BALB/c mouse model. These findings further define the contributions of the htrA gene product to the pathogenesis of B. abortus infections.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82aa3aa3ad796706169f424a3951162 https://pubmed.ncbi.nlm.nih.gov/8890248 Zobrazit plný text záznamu