| Autor: |
Anand S, Tegginamani, Vanishree H, Shivakumar, Siti Mazlipah B, Ismail, Mannil T, Abraham, Bennete A, Fernandes, Ahmad Termizi B, Zamzuri |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 32(2) |
| ISSN: |
1681-7168 |
| Popis: |
Oral leukoplakia is the most common potentially malignant oral disorder. Oral leukoplakia's malignant potential is independent of the histopathological grade, and the malignant transformation rate varies greatly from 3% to 50% even in the case of severe epithelial dysplasia. Ethnicenvironmental variables may contribute to this variation. C-kit immunohistochemistry was performed on 15 oral leukoplakia (OL), two oral squamous cell carcinoma (OSCC), and two dentigerous cysts (DC). The objective of this study was to evaluate the c-kit expression in oral leukoplakia. The use of various immunohistochemical markers to differentiate between OLs with a high and low risk of malignant transformation has been investigated. Only four OL exhibited a faint cytoplasmic expression in basal cells. Whereas, OSCC and DC were devoid of c-kit expression. Thus, this may not be a unique marker for identifying OL at high-risk. Further research with larger sample size is required. Key Words: CD 117, Disease progression, Oral dysplasia, Oral leukoplakia, Risk prediction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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