ISLET CELL ANTIBODIES IN CHILDREN WITH MUMPS INFECTION
| Autor: | W.R. Willems, K. Helmke, A. Otten |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
endocrine system diseases
Cell Human leukocyte antigen Mumps virus medicine.disease_cause Virus Islets of Langerhans Immune system Diabetes mellitus Diabetes Mellitus Humans Medicine Child Mumps Autoantibodies geography geography.geographical_feature_category biology business.industry General Medicine Islet medicine.disease Virology medicine.anatomical_structure Virus Diseases biology.protein Antibody business |
| Zdroj: | The Lancet. 316:211-212 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(80)90105-1 |
| Popis: | Mumps infection was the first and still is the most frequently mentioned virus infection in connection with the development of type I diabetes mellitus. In 21 mumps-infected children islet cell antibodies were demonstrated during 1979 to 1981. These positive results could not be obtained in the subsequent years. Islet cell surface antibodies, however were detectable in a high percentage of patients infected with mumps as well as with other viruses. All but one of those patients showing anti-islet cell immune activity did not develop diabetes mellitus. Their HLA constellation was not comparable with those of type I diabetic patients. In contrast the HLA constellation of 7 children who developed diabetes mellitus shortly after mumps vaccination did include DR4 in each case as well as DR3 in 3 cases. |
| Databáze: | OpenAIRE |
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