123I-ioflupane brain SPECT and 123I-MIBG cardiac planar scintigraphy combined use in uncertain parkinsonian disorders
| Autor: | Giuseppe Madeddu, Angela Spanu, Aldo Mulas, Antonio Nieddu, Pier Andrea Serra, Grazia Galleri, M.R. Piras, Gaia Giovanna Maria Rocchitta, Susanna Nuvoli |
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| Rok vydání: | 2017 |
| Předmět: |
Male
uncertain parkinsonism Nortropanes Observational Study Single-photon emission computed tomography Multimodal Imaging 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Parkinsonian Disorders 123I-ioflupane SPECT medicine Humans Dementia Aged Retrospective Studies Aged 80 and over Tomography Emission-Computed Single-Photon medicine.diagnostic_test Lewy body business.industry Parkinsonism Brain Mediastinum Heart Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging 3-Iodobenzylguanidine 123I-MIBG cardiac scintigraphy medicine.anatomical_structure Female Radiopharmaceuticals Alzheimer's disease Differential diagnosis Nuclear medicine business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| Popis: | We evaluated the clinical usefulness of the combined use of 123I-ioflupane brain single photon emission computed tomography (SPECT) and 123I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy in discriminating uncertain parkinsonism with vascular lesions in striatal nuclei at magnetic resonance imaging (MRI). Forty-three consecutive patients with uncertain parkinsonism and vascular lesions at MRI in striatal nuclei were retrospectively evaluated; the uncertain differential diagnosis was between Parkinson's disease and vascular parkinsonism (PD/VP) in 22 patients, between PD and other neurodegenerative parkinsonism (PD/PS) in 11 patients and between Lewy body dementia and Alzheimer disease (LBD/AD) in the remaining 10 cases. All patients underwent 123I-ioflupane SPECT with striatal dopaminergic activity determination as binding potentials (BP; cut-off: 3.3). 123I-MIBG cardiac planar scintigraphy was performed 2 weeks later, in early (15 minutes) and delayed (240 minutes) phases also calculating heart to mediastinum (H/M) ratio (cut-off: 1.56). 123I-Ioflupane uptake was normal in 9 patients with BP values >3.3, while it was reduced in 34/43 cases with BP values 1.56 in all cases; the uptake was reduced in 22/43 cases, (4 of whom were normal and 18 were with 123I-ioflupane striatal defects) with the H/M ratio |
| Databáze: | OpenAIRE |
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