Myelinated Retinal Nerve Fiber Progression in a 10-Year Follow-Up. The Beijing Eye Study 2001/2011
| Autor: | Zhe Pan, Wen Bin Wei, Qi Zhang, Chuan Chuan Wei, Xiao-Yan Peng, Hua Yang, Liang Xu, Ya Xing Wang, Jost B. Jonas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Population Optic Disk Nerve fiber Fundus (eye) Nerve Fibers Myelinated Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Humans education 030304 developmental biology 0303 health sciences education.field_of_study 10 year follow up business.industry Retinal eye diseases Myelinated retinal nerve fibers medicine.anatomical_structure chemistry Beijing Cohort 030221 ophthalmology & optometry sense organs business Cohort study Follow-Up Studies |
| Zdroj: | American journal of ophthalmology. 230 |
| ISSN: | 1879-1891 |
| Popis: | Purpose To assess the prevalence of myelinated retinal nerve fibers (MRNFs), the rate of their change in a 10-year follow-up, and associations with ocular and systematic parameters in a population-based cohort. Design Longitudinal population-based cohort study. Methods The Beijing Eye study including 4,439 participants aged 40+ years in 2001 and was repeated in 2011, with 2,695 individuals (66.4% of the surviving) being re-examined in 2011. All participants underwent detailed physical and ocular examinations. MRNFs were diagnosed on fundus photographs and their change was assessed using a flicker method of fundus photographs. Results Out of 35 eyes (29 participants) with detected MRNFs at baseline (mean prevalence: 0.4% ± 0.26% per eye or 0.7% ± 0.41% per individual), 23 eyes from 20 individuals (17 [85%] participants with unilateral MRNFs) were re-examined in 2011. MRNF enlargement was detected in all 19 eyes (100%) with clear fundus photographs. The mean MRNF area increased from 4,233 ± 3,670 µm2 (range: 178-11,643 µm2) at baseline to 5,243 ± 4,092 µm2 (range: 196-13,297 µm2) at follow-up (P Conclusions MRNFs (mean prevalence per eye: 0.4%) showed, in association with higher LDL serum concentration and peripheral located MRNF, an enlargement during a 10-year follow-up, while in the same period no new MRNFs were detected in the total study cohort. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect