Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors
| Autor: | Per Hall, Diana Eccles, Peter Dabrock, Sabine C. Linn, Tade Spranger, Peter Devilee, Judith Balmaña, Kerstin Rhiem, Stefania Boccia, Björn Schmitz-Luhn, Bettina Borisch, Christiane Woopen, Alexander Katalinic, Wolfgang Gaissmaier, Dominique Stoppa-Lyonnet, Stefanie Houwaart, Rita K. Schmutzler, Paul D.P. Pharoah, Marc van den Bulcke, Karin Kast, Jacek Gronwald, Johannes Jozef Marten van Delden, Stefan Huster, Sowmiya Moorthie, Günter Emons |
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| Přispěvatelé: | Institut Català de la Salut, [Schmutzler RK] Center Familial Breast and Ovarian Cancer and Center of Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany. [Schmitz-Luhn B] Cologne Center for Ethics, Rights, Economics, and Social Sciences of Health (ceres), University of Cologne, and Research Unit Ethics, University Hospital of Cologne, Cologne, Germany. [Borisch B] Institute of Global Health, University of Geneva, Geneva, Switzerland. [Devilee P] Leids Universitair Medisch Zentrum, Universiteit Leiden, Leiden, The Netherlands. [Eccles D] Clinical Trials Unit, University of Southampton, Southampton, UK. [Hall P] Karolinska Institutet, Stockholm, Sweden. [Balmaña J] Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Rok vydání: | 2021 |
| Předmět: |
ELSI ethical
Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores] medicine.medical_specialty social implications Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES] diagnóstico::diagnóstico precoz::detección precoz del cáncer [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Review Article Risk-adjusted prevention técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Individual risk Other subheadings::Other subheadings::/prevention & control [Other subheadings] Breast cancer ddc:150 Cancer screening Medicine Mama - Càncer - Diagnòstic Intensive care medicine Settore MED/42 - IGIENE GENERALE E APPLICATA legal Risk adjusted neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES] Cancer prevention business.industry Early disease Evidence-generating care Mama - Càncer - Factors de risc Increased risk Mama - Càncer - Prevenció Oncology Preventive intervention Risk-adjusted prevention · Breast cancer · Evidencegenerating care · ELSI ethical legal social implications Surgery Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Genetic risk factor business ELSI ethical legal social implications Diagnosis::Early Diagnosis::Early Detection of Cancer [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] |
| Zdroj: | Breast Care, 17(2), 208-223. KARGER Scientia Breast Care (Basel) |
| ISSN: | 1661-3805 1661-3791 |
| Popis: | Breast cancer; Evidence-generating care; Risk-adjusted prevention Cáncer de mama; Atención generadora de evidencia; Prevención ajustada al riesgo Càncer de mama; Atenció generadora d'evidències; Prevenció ajustada al risc Background: Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increased risk is identified. However, collecting proof of effective preventive measures, ideally by prospective randomized preventive studies, typically requires very long periods of time, while the knowledge about an increased risk immediately creates a high demand for action. Summary: Therefore, we propose a risk-adjusted prevention concept that is based on the best current evidence making needed and appropriate preventive measures available, and which is constantly evaluated through outcome evaluation, and continuously improved based on these results. We further discuss the structural and procedural requirements as well as legal and socioeconomical aspects relevant for the implementation of this concept. The project was funded by the German Federal Ministry of Health (grant No. 2515FSB401 to Rita Schmutzler and Christiane Woopen) for supporting the international expert meetings, and a grant of the EU Horizon 2020 program, BRIDGES (grant No. 634935, PI Peter Devilee, WP5-PI Rita Schmutzler), for the compilation of the most recent findings of genetic risk prediction. |
| Databáze: | OpenAIRE |
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