Vitamin D3 metabolite ratio as an indicator of vitamin D status and its association with diabetes complications

Autor: Stephen L. Atkin, Soha R. Dargham, Charbel Abi Khalil, Alexandra E. Butler, Lina Ahmed, Omar Chidiac, Aishah Latif
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Vitamin
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Population
030209 endocrinology & metabolism
Type 2 diabetes
Gastroenterology
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Vitamin D metabolites
vitamin D deficiency
Diabetic complications
Diabetes Complications
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Vitamin D metabolite ratio
Diabetes mellitus
Internal medicine
medicine
Vitamin D and neurology
Humans
Vitamin D
education
Cholecalciferol
education.field_of_study
lcsh:RC648-665
Vitamin D deficiency
business.industry
General Medicine
Diabetic retinopathy
Vitamins
Middle Aged
medicine.disease
Prognosis
030104 developmental biology
Cross-Sectional Studies
chemistry
Diabetes Mellitus
Type 2
Female
business
Dyslipidemia
Biomarkers
Research Article
Follow-Up Studies
Zdroj: BMC Endocrine Disorders
BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-8 (2020)
ISSN: 1472-6823
Popis: Background Vitamin D deficiency is diagnosed by total serum 25-hydroxyvitamin D (25(OH)D) concentration and is associated with poor health and increased mortality; however, some populations have low 25(OH) D concentrations without manifestations of vitamin D deficiency. The Vitamin D Metabolite Ratio (VMR) has been suggested as a superior indicator of vitamin D status. Therefore, VMR was determined in a population with type 2 diabetes at high risk for vitamin D deficiency and correlated with diabetic complications. Research design and methods Four hundred sisty patients with type 2 diabetes (T2D) were recruited, all were vitamin D3 supplement naive. Plasma concentration of 25-hydroxyvitamin D3 (25(OH)D3) and its metabolites 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) and its epimer, 3-epi-25-hydroxyvitamin D3 (3-epi-25(OH)D3), were measured by LC-MS/MS analysis. VMR-1 was calculated as a ratio of 24,25(OH)2D3:25(OH)D3; VMR-2 as a ratio of 1,25(OH)2D3:25(OH)D3; VMR-3 was calculated as a ratio of 3-epi-25(OH)D3: 25(OH)D3. Results An association means that there were significant differences between the ratios found for those with versus those without the various diabetic complications studied. VMR-1 was associated with diabetic retinopathy (p = 0.001) and peripheral artery disease (p = 0.012); VMR-2 associated with hypertension (p p p p p = 0.001) and stroke (p p p p Conclusions In this cross sectional study, whilst not causal, VMR-2 was shown to be the superior predictor of diabetic and cardiovascular complications though not demonstrative of causality in this cross-sectional study population over VMR-1, VMR-3 and the individual vitamin D concentration measurements; VMR-2 associated with both microvascular and cardiovascular indices and therefore may have utility in predicting the development of diabetic complications.
Databáze: OpenAIRE
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