Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study

Autor:	Mattias AS Henning, Christoffer E. Hother, Karina Banasik, Kristina S. Ibler, Sisse Rye Ostrowski, Christian Erikstrup, Kaspar R. Nielsen, Henrik Ullum, Henrik Hjalgrim, Thomas F. Hansen, Kathrine A. Kaspersen, Betina S. Sørensen, Susanne G. Sækmose, Gregor B. E. Jemec, Ole B. Pedersen
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	HLA-A Antigens Denmark Histocompatibility Antigens Class I Immunology Histocompatibility Antigens Class II Blood Donors General Medicine HLA Antigens Humans Hyperhidrosis blood donors hyperhidrosis HLA antigens Retrospective Studies
Zdroj:	Henning, M AS, Hother, C E, Banasik, K, Ibler, K S, Ostrowski, S R, Erikstrup, C, Nielsen, K R, Ullum, H, Hjalgrim, H, Hansen, T F, Kaspersen, K A, Sørensen, B S, Sækmose, S G, Jemec, G B E & Pedersen, O B 2022, ' Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study ', Scandinavian Journal of Immunology, vol. 95, no. 5, e13150 . https://doi.org/10.1111/sji.13150 AS Henning, M, Hother, C E, Banasik, K, Ibler, K S, Rye Ostrowski, S, Erikstrup, C, Nielsen, K R, Ullum, H, Hjalgrim, H, Hansen, T F, Kaspersen, K A, Sørensen, B S, Sækmose, S G, Jemec, G B E & Pedersen, O B 2022, ' Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study ', Scandinavian Journal of Immunology, vol. 95, no. 5, e13150 . https://doi.org/10.1111/sji.13150 AS Henning, M, Hother, C E, Banasik, K, Ibler, K S, Rye Ostrowski, S, Erikstrup, C, Nielsen, K R, Ullum, H, Hjalgrim, H, Hansen, T F, Kaspersen, K A, Sørensen, B S, Sækmose, S G, Jemec, G B E & Pedersen, O B 2022, ' Hyperhidrosis and human leucocyte antigens in the Danish Blood Donor Study ', Scandinavian Journal of Immunology, vol. 95, no. 5 . https://doi.org/10.1111/sji.13150
DOI:	10.1111/sji.13150
Popis:	Familial clustering of the skin disease primary hyperhidrosis suggests a genetic component to the disease. The human leucocyte antigen (HLA) is implicated in a range of diseases, including many comorbidities to hyperhidrosis. No study has investigated whether the HLA genes are involved in the pathogenesis of hyperhidrosis. We, therefore, compared HLA alleles in individuals with and without hyperhidrosis in this study of 65 000 blood donors. In this retrospective cohort study, we retrieved information on individuals with and without hyperhidrosis using self-reported questionnaires, the Danish National Patient Registry and the Danish National Prescription Registry on participants recruited to the Danish Blood Donor Study between 2010 and 2019. Association tests using logistic regression were conducted for each HLA allele corrected for sex, age, body mass index, smoking and principal components. Overall, 145 of 65 795 (0.2%) participants had hospital diagnosed hyperhidrosis. Similarly, 1379 of 15 530 (8.9%) participants had moderate-severe self-reported hyperhidrosis, of whom 447 (2.9%) had severe self-reported hyperhidrosis. Altogether, 28 participants had both hospital diagnosed and moderate-severe self-reported hyperhidrosis. Severe self-reported hyperhidrosis was associated with HLA-A*80:01 (adjusted odds ratio 26.97; 95% confidence interval 5.32-136.70; n = 7; P
Databáze:	OpenAIRE
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