Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus
| Autor: | Tsugumichi Saito, Hiroto Hoshi, Kazuya Okada, Yasuyo Nakajima, Atsushi Isoda, Shuichi Okada, Junichi Okada, Kihachi Ohshima, Masanobu Yamada, Atsushi Ozawa, Eijiro Yamada, Takuya Watanabe |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Deiodinase DIO2 030209 endocrinology & metabolism Iodide Peroxidase 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Humans Insulin Medicine Euthyroid Aged Retrospective Studies Aged 80 and over Glycated Hemoglobin biology business.industry Type 2 Diabetes Mellitus Middle Aged medicine.disease Polycystic ovary Thyroxine Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Iodothyronine deiodinase biology.protein Triiodothyronine Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine Journal. 68:1237-1240 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.ej21-0169 |
| Popis: | Free triiodothyronine/free thyroxine (FT3/FT4) ratio is considered as an index of the activities of iodothyronine deiodinase types 1 and 2 (DIO1 and DIO2, respectively) and is reportedly associated with insulin resistance in euthyroid adults. Euthyroid women with polycystic ovary syndrome accompanied with insulin resistance have lesser deiodinase activities. Correspondingly, the serum insulin level in a fasted condition positively correlates with the FT3/FT4 ratio, and insulin depletion decreases the DIO2 activity in mice. Selected genetic variants in DIO1 are also associated with insulin resistance measures. Therefore, if insulin positively regulates DIO1 and DIO2, the FT3/FT4 ratio should decrease under impaired insulin action, and the casual insulin level and FT3/FT4 ratio should be negatively correlated. To evaluate this hypothesis, we conducted a single-center retrospective study between 2018 and 2021. All participants visited the selected hospitals monthly for type 2 diabetes mellitus treatment and casual plasma glucose and HbA1c level measurements. Furthermore, their casual serum insulin levels were measured annually. Meanwhile, we excluded patients treated with insulin injection. Ultimately, we evaluated 71 patients, which all exhibited euthyroid conditions. The FT3/FT4 ratio was independently associated with thyroid-stimulating hormone, casual plasma glucose, and casual insulin levels. In terms of the regression coefficients of the univariate linear regression analysis, the FT3/FT4 ratio negatively correlated with the casual serum insulin levels. Therefore, the risk of FT3/FT4 ratio underestimation should be considered when diagnosing Graves' disease, which is often accompanied with insulin resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|