Neuromechanical Model of Rat Hindlimb Walking with Two-Layer CPGs
| Autor: | Alexander J. Hunt, Roger D. Quinn, Martin S. Fischer, Dirk Arnold, Nicholas S. Szczecinski, Kaiyu Deng, Emanuel Andrada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nervous system
Biomedical Engineering Fictive motion Bioengineering Sensory system Hindlimb Biology Biochemistry lcsh:Technology Article Biomaterials 03 medical and health sciences synthetic nervous system 0302 clinical medicine pattern formation Rhythm generator muscle synergies medicine Biological neural network rat 030304 developmental biology 0303 health sciences lcsh:T rhythm generator Spinal cord Sagittal plane medicine.anatomical_structure Molecular Medicine Neuroscience 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Biomimetics, Vol 4, Iss 1, p 21 (2019) Biomimetics Volume 4 Issue 1 |
| ISSN: | 2313-7673 |
| Popis: | This work demonstrates a neuromechanical model of rat hindlimb locomotionundergoing nominal walking with perturbations. In the animal, two types of responses toperturbations are observed: resetting and non-resetting deletions. This suggests that the animallocomotor system contains a memory-like organization. To model this phenomenon, we built asynthetic nervous system that uses separate rhythm generator and pattern formation layers toactivate antagonistic muscle pairs about each joint in the sagittal plane. Our model replicates theresetting and non-resetting deletions observed in the animal. In addition, in the intact (i.e., fullyafferented) rat walking simulation, we observe slower recovery after perturbation, which isdifferent from the deafferented animal experiment. These results demonstrate that our model is abiologically feasible description of some of the neural circuits in the mammalian spinal cord thatcontrol locomotion, and the difference between our simulation and fictive motion shows theimportance of sensory feedback on motor output. This model also demonstrates how the patternformation network can activate muscle synergies in a coordinated way to produce stable walking,which motivates the use of more complex synergies activating more muscles in the legs for threedimensionallimb motion. |
| Databáze: | OpenAIRE |
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