Single-agent chemotherapy versus combination chemotherapy in advanced non-small cell lung cancer: a quality and meta-analysis study
| Autor: | Pietro Di Marino, Alessandra Cantoni, Gianfranco Buccheri, Armando Preatoni |
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| Rok vydání: | 1995 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Antineoplastic Agents law.invention Randomized controlled trial Quality of life law Internal medicine Carcinoma Non-Small-Cell Lung Antineoplastic Combined Chemotherapy Protocols medicine Humans Lung cancer Survival analysis Randomized Controlled Trials as Topic business.industry Reproducibility of Results Combination chemotherapy Odds ratio medicine.disease Confidence interval Surgery Meta-analysis business |
| Zdroj: | Lung cancer (Amsterdam, Netherlands). 13(1) |
| ISSN: | 0169-5002 |
| Popis: | Study objective : To estimate the quality of the studies and to compare single-agent with combination chemotherapy in advanced non-small cell lung cancer. Design : Identification of published randomized trials and extraction of essential results directly from the published reports. Measurements and results : Survival probability at 1 year, as estimated from the published survival curves, has been considered as the end-point of interest. Quality scoring of the studies has also been performed. Arithmetical calculation, concerning the estimation of quantities necessary for the meta-analysis of the literature, has been addressed. The estimated pooled Odds Ratio of death was 0.8, with 95% confidence interval of 0.6–1.0, thus favoring combination chemotherapy. Conclusions : The results of our meta-analysis favor combination chemotherapy. They must, however, be considered in the light of their clinical relevance and of the balance between quality of life, toxicity and costs of chemotherapy. |
| Databáze: | OpenAIRE |
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