Review of vascularized bone marrow transplantation: Current status and future clinical applications
| Autor: | Charles W. Hewitt, R D O Chad Gordon, Hidetoshi Suzuki, Louise F. Strande, Martha S. Matthews, Rajendra Ramsamooj, Chau Y. Tai, Kirby S. Black |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
medicine.medical_specialty Stromal cell Bone marrow transplantation medicine.medical_treatment Graft vs Host Disease Chimerism Immune tolerance Mice Bone Marrow Internal medicine Immune Tolerance medicine Animals Bone Marrow Transplantation Immunosuppression Therapy business.industry Immunosuppression Transplantation Transplantation Isogeneic Tolerance induction surgical procedures operative medicine.anatomical_structure Vascularized bone Models Animal Immunology Surgery Bone marrow business Stem Cell Transplantation |
| Zdroj: | Microsurgery. 27:348-353 |
| ISSN: | 1098-2752 0738-1085 |
| Popis: | In this review, we examine the applicability of the vascularized bone marrow transplant (VBMT) as an alternative to conventional bone marrow transplantation (BMT). As a new surgical approach, the VBMT is unique by transplantation of the stromal environment that eliminates the need for an engraftment period, provides critical signaling and modulatory functions, and may potentiate tolerance induction. Thus far, VBMT studies have demonstrated an absence of graft-versus-host disease (GVHD) and robust engraftment into nonmanipulated as well as irradiated recipients with evidence of immunological tolerance. Further investigation is needed to determine the applicability of VBMT as an alternative to BMT. |
| Databáze: | OpenAIRE |
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