Data on the modulatory effects of a single bolus dexamethasone on the surface marker expression of various leucocyte subsets
| Autor: | Kiymet Bozaoglu, Tomas Corcoran, Rachael L. Taylor, O. Gouldthorpe, Paul S. Myles, C. R. Bain, Dominik F. Draxler, Sophie Wallace, Robert L. Medcalf |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
PBMCS
peripheral blood mononuclear cells Inflammation lcsh:Computer applications to medicine. Medical informatics Peripheral blood mononuclear cell Dexamethasone 03 medical and health sciences 0302 clinical medicine Immune system medicine Leukocytes MFI mean fluorescence intensity Immune response lcsh:Science (General) Glucocorticoids 030304 developmental biology 0303 health sciences Multidisciplinary Innate immune system business.industry CDC conventional dendritic cells Monocyte Medicine and Dentistry Treg regulatory T cells SSC side scatter medicine.anatomical_structure Immunology lcsh:R858-859.7 Flowcytometry medicine.symptom business 030217 neurology & neurosurgery CD8 Glucocorticoid lcsh:Q1-390 medicine.drug |
| Zdroj: | Data in Brief Data in Brief, Vol 32, Iss, Pp 106117-(2020) |
| ISSN: | 2352-3409 |
| Popis: | Dexamethasone is frequently administered to surgical patients for anti-emetic prophylaxis. We have examined the immunomodulatory effects of a single bolus of dexamethasone on circulating peripheral blood mononuclear cells (PBMCs) in the same 10 healthy male volunteers, previously used in our investigation on early in vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation [1] . Blood samples were drawn at baseline, 2 h, 4 h and 24 h. Immune cell phenotypes were examined with flow cytometry. In this data article the expression strength of markers involved in immune activation and immunosuppression as well as maturation, migration, cell death and responsiveness to signalling on monocyte and cDC subsets, as well as NK cells, CD4+ and CD8+ T cells and regulatory T cells (Treg) are presented. These data improve our understanding of the immunomodulatory effects of the glucocorticoid dexamethasone in-vivo, which may be important for the optimisation of treatment regimens as well as the evaluation of new indications for glucocorticoid treatment. |
| Databáze: | OpenAIRE |
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