25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth
| Autor: | M. E. Breen, Norman K. Pollock, Richard D. Lewis, Dorothy B. Hausman, Ruth G. Taylor, Kehong Ding, Emma M. Laing, Daniel B. Hall, Carlos M. Isales, Clifton A. Baile, Mark W. Hamrick |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Bone density Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Context (language use) Biology Biochemistry Insulin-like growth factor Endocrinology Calcification Physiologic Bone Density Internal medicine medicine Vitamin D and neurology Humans Prospective Studies Insulin-Like Growth Factor I Vitamin D Prospective cohort study Child Bone mineral Analysis of Variance Biochemistry (medical) digestive oral and skin physiology medicine.disease humanities Diet Child Preschool Body Composition Linear Models Female Original Article Analysis of variance Calcification |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 96(1) |
| ISSN: | 1945-7197 |
| Popis: | The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear. OBJECTIVE, SETTING, AND PARTICIPANTS: This study sought to determine relationships among 25(OH)D, IGF-I, and BMC in community-dwelling prepubertal females (n = 76; aged 4-8 yr at baseline) over a period of up to 9 yr.The hypothesis that changes in IGF-I vs. 25(OH)D are more strongly associated with BMC accrual was formulated after data collection. 25(OH)D and IGF-I were log-transformed and further adjusted using two-way ANOVA for differences in season and race. Linear mixed modeling (including a random subject-specific intercept and a random subject-specific slope on age) was employed to analyze the proportion of variance the transformed 25(OH)D and IGF-I variables explained for the bone outcomes.IGF-I was more strongly associated with BMC accrual than 25(OH)D at the total body (R(2) = 0.874 vs. 0.809), proximal femur (R(2) = 0.847 vs. 0.771), radius (R(2) = 0.812 vs. 0.759), and lumbar spine (R(2) = 0.759 vs. 0.698). The rate of BMC accrual was positively associated with changes in IGF-I but negatively associated with 25(OH)D. When IGF-I and 25(OH)D were included in the same regression equation, 25(OH)D did not have a significant predictive effect on BMC accrual above and beyond that of IGF-I.These prospective data in early adolescent females indicate that both 25(OH)D and IGF-I have a significant impact on bone mineral accrual; however, the positive association of IGF-I and BMC accrual is greater than the negative association of 25(OH)D and BMC accrual. |
| Databáze: | OpenAIRE |
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