The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity
| Autor: | V. M. Lyapin, Shchegolev Ai, R. G. Shmakov, Gennady T. Sukhikh, G V Kulikova |
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| Rok vydání: | 2021 |
| Předmět: |
Vascular Endothelial Growth Factor A
Pathology medicine.medical_specialty placenta H&E stain Biology Article General Biochemistry Genetics and Molecular Biology Syncytiotrophoblast Pregnancy Placenta medicine Humans reproductive and urinary physiology novel coronavirus infection (COVID-19) SARS-CoV-2 COVID-19 food and beverages General Medicine syncytial knots Hypoxia (medical) medicine.disease Immunohistochemistry VEGF Vascular endothelial growth factor A medicine.anatomical_structure embryonic structures Chorionic villi Female Chorionic Villi medicine.symptom |
| Zdroj: | Bulletin of Experimental Biology and Medicine |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-021-05236-x |
| Popis: | A comparative morphological study was carried out to analyze the number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 categorized by the disease severity. The number of syncytial knots was assessed on specimens stained with hematoxylin and eosin. VEGF expression was determined by immunohistochemical analysis in syncytiotrophoblast and villous endothelial cells. Morphological study of the placenta tissue of parturient women with COVID-19 showed increased numbers of syncytial knots in the villi, indicating the development of preplacental hypoxia. High VEGF expression in syncytiotrophoblast and vascular endotheliocytes reflects a stereotyped response to hypoxia and can underlie the development of a preeclampsia-like syndrome. The number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 depended on the disease severity. |
| Databáze: | OpenAIRE |
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