Effect of feeding Chinese herb medicine ageratum-liquid on intestinal bacterial translocations induced by H9N2 AIV in mice

Autor: Che Wu, Huanmin Zhang, Junfang Xiao, Wencheng Lin, Hongxin Li, Haoran Lu, Qingmei Xie, Yihu Chen, Zhengyong Hu, Luxuan Zhang
Rok vydání: 2019
Předmět:
0301 basic medicine
Intestinal microbiota
viruses
animal diseases
Ageratum-liquid
Translocation
Connective tissue
Chromosomal translocation
Ageratum
medicine.disease_cause
Virus
lcsh:Infectious and parasitic diseases
Microbiology
Mice
03 medical and health sciences
0302 clinical medicine
Orthomyxoviridae Infections
Virology
Influenza A Virus
H9N2 Subtype
medicine
Animals
lcsh:RC109-216
Intestinal Mucosa
Barrier function
Mice
Inbred BALB C
Lung
biology
Coinfection
Research
H9N2 avian influenzas virus
Chinese herb medicine
virus diseases
Bacterial Infections
biology.organism_classification
Gastrointestinal Microbiome
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Bacterial Translocation
030211 gastroenterology & hepatology
Staphylococcus
Genome
Bacterial
Bacteria
Drugs
Chinese Herbal
Respiratory tract
Zdroj: Virology Journal
Virology Journal, Vol 16, Iss 1, Pp 1-10 (2019)
ISSN: 1743-422X
Popis: Background As a low pathogenic influenza virus, avian influenza virus subtype H9N2 (H9N2 AIV) often induces high morbidity in association with secondary bacterial infections in chickens or mammals. To explore this phenomenon, the relationship between intestinal microflora changes and bacterial translocations was studied post H9N2 AIV challenge and post AIV infection plus Ageratum-liquid treatment. Methods Illumina sequencing, histological examination and Neongreen-tagged bacteria were used in this study to research the microbiota composition, intestinal barrier, and bacterial translocation in six weeks of BALB/c mice. Results H9N2 AIV infection caused intestinal dysbacteriosis and mucosal barrier damages. Notably, the villus length was significantly reduced (p
Databáze: OpenAIRE
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