P57kip2 immunohistochemical expression and ultrastructural findings of gestational trophoblastic disease and related disorders

Autor: Motoshige Kudo, H. Osawa, Kayoko Tanaka, Shoichiro Mineo, Masumi Akita, Isao Yoshihama, Hiroaki Soma, Koji Fujita, Satoshi Urabe, Tatsuo Oguro, Yoshiki Kudo
Rok vydání: 2007
Předmět:
Adult
medicine.medical_specialty
Pathology
Histogenesis
Biology
Pathology and Forensic Medicine
Diagnosis
Differential
Mesoderm
Syncytiotrophoblast
Pregnancy
Internal medicine
medicine
Biomarkers
Tumor
Humans
Epithelioid Trophoblastic Tumor
Placental site trophoblastic tumor
Gestational Trophoblastic Disease
Molecular Biology
Cyclin-Dependent Kinase Inhibitor p57
reproductive and urinary physiology
Partial Hydatidiform Mole
Gestational trophoblastic disease
Choriocarcinoma
Carcinoma
Trophoblast
General Medicine
Hydatidiform Mole
medicine.disease
Placental Lactogen
Uterine Cervical Dysplasia
Immunohistochemistry
female genital diseases and pregnancy complications
Cyclin-Dependent Kinases
Abortion
Spontaneous
Gene Expression Regulation
Neoplastic
Endocrinology
medicine.anatomical_structure
embryonic structures
Female
Chorionic Villi
Zdroj: Medical molecular morphology. 40(2)
ISSN: 1860-1480
Popis: Gestational trophoblastic disease (GTD) is a unique spectrum of diseases ranging from complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and invasive mole (IM) to choriocarcinoma (CC). Placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT) have been classified as related disorders. Mesenchymal dysplasia (MD) may be misdiagnosed as PHM; however, it is said to have a quite different histogenesis from PHM. P57kip2 is the protein product of a paternally imprinted or maternal gene that inhibits cyclin-dependent kinases (CDK), thus serving to inhibit cell proliferation and to suppress tumor growth. Its lack of expression in trophoblastic disease plays a role in its abnormal proliferation and differentiation. In this study, P57kip2 immunostaining was absent in the trophoblastic layers of CHM and was positive in the trophoblast layer of nonmolar villi and MD. Ultrastructure of complete molar cystic villi showed tree-like branching of microvillous processes and intracytoplasmic lacunae without capillaries in the stroma, whereas MD contained many newly formed blood vessels and collagen. Also, large lacunae with microvilli and polymorphic nuclei of syncytiotrophoblast cells with well-developed organelles were observed in IM. Lung ETT following CHM and normal deliveries showed two types of large mononuclear cells and binuclear cells with abundant organelles and bundles of intermediate-type filaments in the stroma.
Databáze: OpenAIRE
Externí odkaz: