Real-life isoniazid and rifampicin plasma concentrations in children: a tool for therapeutic drug monitoring of tuberculosis
Autor: | Elena Chiappini, Leila Bianchi, Stefania Fallani, Lorenzo Tofani, Barbara Bortone, Luisa Galli, Chiara Tersigni, Andrea Novelli, Giulia Boiardi, Maria Iris Cassetta, Elisabetta Venturini, Carlotta Montagnani |
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Rok vydání: | 2021 |
Předmět: |
Adult
Drug medicine.medical_specialty Tuberculosis Adolescent Dose media_common.quotation_subject Antitubercular Agents Infectious and parasitic diseases RC109-216 Therapeutic drug monitoring Gastroenterology Therapeutic index Internal medicine Isoniazid medicine Humans Child Children Rifampicin Aged media_common medicine.diagnostic_test business.industry Infant Venous blood medicine.disease Infectious Diseases Child Preschool Treatment compliance Drug Monitoring Rifampin business Research Article medicine.drug |
Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021) |
ISSN: | 1471-2334 |
Popis: | Background Low plasma levels of first-line antitubercular drugs can be counted among the main causes of poor response to antitubercular therapy, and therapeutic drug monitoring has been proposed as a method to promote tailored treatments for both child and adult patients. The main aim of the study was to evaluate serum concentrations of isoniazid (INH) and rifampicin (RIF) and to investigate reasons for sub-therapeutic plasma concentrations in order to fix dosages. Methods Children with TB were prospectively enrolled from January to August 2019. Two venous blood samples were collected (the first at least 15 days after the beginning of antitubercular treatment, and the second between 1 and 8 weeks later). Plasma concentrations were determined by a validated high-performance liquid chromatography method. Results In all, 45 children were included. Seventy blood samples for INH plasma concentration were collected between 120 and 240 min after drug intake. Adjusting for dose (mg/kg/day) and time of INH administration, when considering three different age groups (≤ 2 years, 2–12 years, > 12 years), a statistically significant lower INH plasma concentration was observed in younger children compared to the older age groups in the multivariate analysis (p Conclusions Based on our findings, monitoring patients’ drug plasma concentrations in children under 2 years of age and in adolescents can make treatment more patient-tailored. |
Databáze: | OpenAIRE |
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