Point mutation L116R in interferon‐regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells
Autor: | Daniel Staudenraus, Alekhya Porapu, Hanna Leister, Dennis Das Gupta, Michael Lohoff |
---|---|
Rok vydání: | 2022 |
Předmět: | |
Zdroj: | European Journal of Immunology. 52:1680-1683 |
ISSN: | 1521-4141 0014-2980 |
Popis: | IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction of Th9 cells in cells carrying the L116R mutated IRF4. |
Databáze: | OpenAIRE |
Externí odkaz: |