Point mutation L116R in interferon‐regulatory factor 4 differentially impacts key cytokine production in Th2, Th9, and Th17 cells

Autor:	Daniel Staudenraus, Alekhya Porapu, Hanna Leister, Dennis Das Gupta, Michael Lohoff
Rok vydání:	2022
Předmět:	Th2 Cells Interferon Regulatory Factors Immunology Interleukin-9 Cytokines Point Mutation Th17 Cells Immunology and Allergy Cell Differentiation Interferons
Zdroj:	European Journal of Immunology. 52:1680-1683
ISSN:	1521-4141 0014-2980
Popis:	IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction of Th9 cells in cells carrying the L116R mutated IRF4.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8105ca8a48a127db7f8c68132272150 https://doi.org/10.1002/eji.202249869 Zobrazit plný text záznamu Plný text