The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis
| Autor: | Hai Lin, Arun Anantharam, Jefferson D. Knight, Nara L. Chon, Zesen Lin, Skyler L. Jackman, Daniel D. MacDougall |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system Cell type animal structures Physiology Reviews chemistry.chemical_element Review Neurotransmission Calcium Membrane Fusion Exocytosis Synaptotagmin 1 Synaptotagmins 03 medical and health sciences Animals Humans Secretion Chemistry Secretory Vesicles technology industry and agriculture Lipid bilayer fusion 3. Good health Cell biology 030104 developmental biology nervous system Phospholipid Binding lipids (amino acids peptides and proteins) |
| Zdroj: | The Journal of General Physiology |
| ISSN: | 1540-7748 0022-1295 |
| DOI: | 10.1085/jgp.201711944 |
| Popis: | MacDougall et al. review the structure and function of the calcium sensor synaptotagmin-7 in exocytosis. Synaptotagmin (Syt) proteins comprise a 17-member family, many of which trigger exocytosis in response to calcium. Historically, most studies have focused on the isoform Syt-1, which serves as the primary calcium sensor in synchronous neurotransmitter release. Recently, Syt-7 has become a topic of broad interest because of its extreme calcium sensitivity and diversity of roles in a wide range of cell types. Here, we review the known and emerging roles of Syt-7 in various contexts and stress the importance of its actions. Unique functions of Syt-7 are discussed in light of recent imaging, electrophysiological, and computational studies. Particular emphasis is placed on Syt-7–dependent regulation of synaptic transmission and neuroendocrine cell secretion. Finally, based on biochemical and structural data, we propose a mechanism to link Syt-7’s role in membrane fusion with its role in subsequent fusion pore expansion via strong calcium-dependent phospholipid binding. |
| Databáze: | OpenAIRE |
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