Design and synthesis of VEGFR-2 inhibitors based on oleanolic acid moiety

Autor:	Yan-Qiu Meng, Ling Li, Rui-Jie Tong, Peng-Bo Zhang, Yan-Ling Song
Rok vydání:	2019
Předmět:	Stereochemistry VEGF receptors Pharmaceutical Science Molecule docking 01 natural sciences Analytical Chemistry Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Moiety Oleanolic Acid Oleanolic acid Cell Proliferation Pharmacology Molecular Structure biology 010405 organic chemistry Chemistry Organic Chemistry General Medicine Vascular Endothelial Growth Factor Receptor-2 0104 chemical sciences Molecular Docking Simulation 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Homogeneous Drug Design biology.protein Molecular Medicine
Zdroj:	Journal of Asian Natural Products Research. 23:176-188
ISSN:	1477-2213 1028-6020
Popis:	In this study, twenty-four oleanolic acid (OA) derivatives were rationally designed based on molecule docking studies and their VEGFR-2 inhibitory activities were tested by Homogeneous time-resolved fluorescence (HTRF) method
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d810176b9ed3b6be56695cb88d8f835e https://doi.org/10.1080/10286020.2019.1706500 Zobrazit plný text záznamu