Liver transplant after donation from controlled circulatory death versus brain death: A UNOS database analysis and publication bias adjusted meta-analysis
| Autor: | Konstantinos Skarentzos, Alexandra Shingina, Martin I. Montenovo, Christos D. Kakos, Ioannis A. Ziogas, Stepan M. Esagian, Sophoclis P. Alexopoulos |
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| Rok vydání: | 2021 |
| Předmět: |
Transplantation
medicine.medical_specialty Brain Death Tissue and Organ Procurement business.industry Database analysis Hazard ratio Graft Survival Publication bias Cochrane Library Circulatory death Tissue Donors Donation after brain death Liver Transplantation Death Meta-analysis Internal medicine Donation medicine Humans business Publication Bias Retrospective Studies |
| Zdroj: | Clinical transplantationREFERENCES. 36(2) |
| ISSN: | 1399-0012 |
| Popis: | BACKGROUND Donation after circulatory death (DCD) is an increasingly utilized alternative to donation after brain death (DBD) to expand the liver donor pool. We compared the outcomes of liver transplant (LT) after DCD versus DBD. METHODS A PRISMA-compliant systematic literature review was performed using the PubMed, Cochrane Library, and Embase databases (end-of-search-date: July 2, 2020). US outcomes were analyzed using the UNOS database (February, 2002-September, 2020). Pooled hazard ratios (HR) for patient and graft survival were obtained through random effect meta-analyses and adjusted for publication bias. RESULTS Thirteen studies reporting on 1426 DCD and 5385 DBD LT recipients were included. 5620 DCD and 87561 DBD LT recipients were analyzed from the UNOS database. Meta-analysis showed increased risk of patient mortality for DCD (HR = 1.36; 95%CI, 1.09-1.70; P = .01; I2 = 53.6%). When adjusted for publication bias, meta-analysis showed no difference in patient survival between DCD and DBD (HR = 1.15; 95%CI, .91-1.45; P = .25; I2 = 61.5%). Meta-analysis showed increased risk of graft loss for DCD (HR = 1.50; 95%CI, 1.20-1.88; P |
| Databáze: | OpenAIRE |
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