Carotid Plaque, Intima-Media Thickness, and Incident Aortic Stenosis
| Autor: | Kristina Sundquist, J. Gustav Smith, B. Hedblad, Gunnar Engström, Olle Melander, Gerd Östling, Charlotte Andersson, Margaretha Persson, Andreas Martinsson |
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| Rok vydání: | 2014 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty Carotid Artery Common Population Kaplan-Meier Estimate Carotid Intima-Media Thickness Predictive Value of Tests Risk Factors Internal medicine Diabetes mellitus medicine.artery Humans Medicine Prospective Studies Common carotid artery Prospective cohort study education Aged Proportional Hazards Models Sweden education.field_of_study business.industry Incidence Aortic Valve Stenosis Middle Aged medicine.disease Plaque Atherosclerotic Surgery Stenosis Intima-media thickness Aortic valve stenosis Multivariate Analysis Cardiology Female Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 34:2343-2348 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Objective— Aortic stenosis (AS) shares risk factors with atherosclerotic vascular disease. Carotid intima-media thickness (IMT) and plaque may reflect the cumulative damage from exposure to different atherosclerotic risk factors. We examined the relationship of carotid IMT and plaque with incident AS in a prospective population-based study. Approach and Results— A random sample of participants (age, 45–68 years) in the population-based Malmö Diet and Cancer Study underwent B-mode ultrasound with measurements of IMT and the presence of plaque in the common carotid artery (n=5079). Potential risk factors for incident AS were studied in age- and sex-adjusted and expanded multivariable-adjusted Cox regression models. A total of 69 (1.4%) participants developed AS during up to 20 years of follow-up. Significant risk factors for AS in age- and sex-adjusted analyses were ( P P >0.05). After adjustments, IMT, plaque, age, smoking, C-reactive protein, low-density lipoprotein cholesterol, and diabetes mellitus remained significantly associated with incident AS. IMT was no longer significantly associated with AS after adjustments for plaque and systolic blood pressure, but plaque remained significantly associated with incident AS. Conclusions— Traditional cardiovascular risk factors were individually associated with incident AS, and in multivariable models low-density lipoprotein cholesterol, smoking, age, presence of plaque, C-reactive protein, and diabetes mellitus remained significant predictors of incident AS. AS represents a vascular disorder related to carotid plaque, with potential implications for the pathophysiology and prevention of this disease. |
| Databáze: | OpenAIRE |
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