Effects of X-Ray Irradiation of Female Mice in Preconceptive Period on Polymorphism of Simple Repeats in DNA of Offspring of Different Sex
| Autor: | M. G. Lomaeva, V. G. Bezlepkin, L. A. Fomenko |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Tail Offspring Somatic cell Mitosis Spleen Biology Polymerase Chain Reaction Epithelium General Biochemistry Genetics and Molecular Biology law.invention Andrology Mice chemistry.chemical_compound Sex Factors Pregnancy law medicine Animals Polymerase chain reaction Mice Inbred BALB C Polymorphism Genetic X-Rays Brain Dose-Response Relationship Radiation DNA General Medicine medicine.disease Molecular biology medicine.anatomical_structure chemistry Maternal Exposure Prenatal Exposure Delayed Effects Female Estrus Synchronization Whole-Body Irradiation Microsatellite Repeats |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 152:431-434 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-012-1546-6 |
| Popis: | Sibs groups of F1-offspring born by non-irradiated mice and by female mice exposed to X-ray radiation in preconceptive period (50-200 cGy) were compared. Arbitrary primed PCR revealed significantly increased polymorphism of simple DNA repeats in somatic tissues of the offspring from female mice irradiated in a dose of 200 cGy. The increase in DNA polymorphism in postmitotic brain tissues and in peripheral blood was more pronounced than in proliferating spleen tissues and in the epithelium of tail tip. In the tissues of female offspring from irradiated mothers, higher increase in DNA polymorphism was observed in comparison with the tissues of male offspring from the same mothers. |
| Databáze: | OpenAIRE |
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