Studies on the mechanism of protection by aurintricarboxylic acid in beryllium poisoning. V. Long-term distribution studies with C14-labeled ATA
| Autor: | Arthur Lindenbaum, Marcia R. White, Jack Schubert |
|---|---|
| Rok vydání: | 1954 |
| Předmět: |
medicine.medical_specialty
Kidney Chemistry Poisoning Aurintricarboxylic Acid Biophysics Soft tissue Spleen Single injection Biochemistry chemistry.chemical_compound Endocrinology medicine.anatomical_structure Internal medicine Toxicity Aurintricarboxylic acid medicine Distribution (pharmacology) Carbon-14 Beryllium Coloring Agents Molecular Biology |
| Zdroj: | Archives of biochemistry and biophysics. 52(1) |
| ISSN: | 1096-0384 |
| Popis: | 1. 1. The distribution of a single injection of C 14 -methyl-labeled aurintricarboxylic acid (ATA) in tissues was determined over a period of 8 months in rats, and after 24 hr. in dogs. 2. 2. The levels of ATA retained in all rat tissues studied 24 hr. after administration were retained for as long as 1–3 months. The highest concentrations were found in kidney, spleen, and liver. There were measurable amounts in all tissues for as long as 8 months. 3. 3. ATA appeared to be uniformly distributed in soft tissues, presumably as a protein-ATA complex, and was not detected in inorganic bone. |
| Databáze: | OpenAIRE |
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