Beclin-1 increases with obstructive sleep apnea severity
| Autor: | Frédéric Schlemmer, Bernard Maitre, Sophie Lanone, Bruno Ribeiro Baptista, Audrey Ridoux, Serge Adnot, Maeva Zysman, Laurent Boyer, Philippe Le Corvoisier, Jorge Boczkowski, Ala Noroc, Geneviève Derumeaux, Etienne Audureau |
|---|---|
| Přispěvatelé: | Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Plateforme de Ressources Biologiques [Henri Mondor AP-HP, Créteil] (PRB), CHU Henri Mondor-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Clinical Epidemiology and Ageing : Geriatrie Soins Primaires et Santé Publique (CEpiA), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHI Créteil, Centre d'Investigation Clinique Henri Mondor (CIC Henri Mondor), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Lanone, Sophie, IMRB - GEIC2O/'Genetic and Environmental Interactions in COPD, Cystic fibrosis and Other (rare) respiratory diseases' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Henri Mondor |
| Rok vydání: | 2021 |
| Předmět: |
Bioinformatics
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Pathogenesis 03 medical and health sciences 0302 clinical medicine Relative resistance Autophagy Animals Humans Medicine Beclin1 Hypoxia Sleep Apnea Obstructive business.industry Intermittent hypoxia Biomarker General Medicine Hypoxia (medical) medicine.disease Obstructive sleep apnea Chronic disorders 030228 respiratory system [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Biomarker (medicine) Beclin-1 medicine.symptom business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Sleep Medicine Sleep Medicine, Elsevier, 2021, 81, pp.474-476. ⟨10.1016/j.sleep.2021.03.017⟩ Sleep Medicine, 2021, 81, pp.474-476. ⟨10.1016/j.sleep.2021.03.017⟩ |
| ISSN: | 1389-9457 |
| Popis: | International audience; Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults. Adaptative pathways induced by hypoxia could implicate autophagic processes and Beclin-1, one of the first mammalian autophagy effectors. Thus, activation of autophagy could protect against cardiovascular events in patients with OSA and could be considered as biomarker of a better prognosis. |
| Databáze: | OpenAIRE |
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