Enantioselective synthesis of nicotinic receptor probe 7,8-difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine

Autor:	Teresa W. Makowski, Ruth E. McDermott, Paige Roanne Palmer Brooks, Michael C. Wirtz, Crystal G. Bashore, Michael G. Vetelino, John A. Ragan, David C. Whritenour, Jotham Wadsworth Coe, Heather N. Frost, Steven J. Brenek, Jennifer Lea Rutherford
Rok vydání:	2006
Předmět:	Models Molecular Nicotine Chemistry Stereochemistry Alkaloid Organic Chemistry Enantioselective synthesis Stereoisomerism Alkylation Receptors Nicotinic Crystallography X-Ray Biochemistry Benzazocine chemistry.chemical_compound Nicotinic agonist Molecular Probes Physical and Theoretical Chemistry Receptor Trifluoromethanesulfonate
Zdroj:	Organic letters. 8(26)
ISSN:	1523-7060
Popis:	[Structure: see text] The development of a concise enantioselective synthesis of nicotinic alkaloid 1 is presented. The route features the synthesis and use of a "stable" aliphatic triflate 21 in an alkylation step to generate Heck precursor 24 and an enantioselective cyclization to establish a compound with the key [3.2.1]-bicyclic core, 29.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80965a90b4448a18d3169e58916042b https://pubmed.ncbi.nlm.nih.gov/17165901 Zobrazit plný text záznamu