The expression and clinical value of tumor infiltrating dendritic cells in tumor tissues of patients with esophageal cancer
| Autor: | Yanzhi Pei, Yanzhi Zhu, Xiaolin Wang, Lin Xu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Gastroenterology chemical and pharmacologic phenomena Esophageal cancer medicine.disease Tumor tissue Lesion Immune system Oncology Internal medicine Clinical value Medicine Original Article Stage (cooking) medicine.symptom business CD8 Major histocompatibility |
| Zdroj: | J Gastrointest Oncol |
| ISSN: | 2078-6891 |
| Popis: | BACKGROUND: As dendritic cells (DCs) are the major antigen-presenting cells of the immune system, understanding their role in esophageal cancer is essential for the development of preventative and treatment strategies. This study investigated the expression level and clinical value of tumor infiltrating dendritic cells (TIDCs) in tumor tissues of patients with esophageal cancer. METHODS: From January 2019 to January 2021, 184 patients with esophageal cancer treated were prospectively enrolled as the observation group and 184 patients with benign esophageal tumors were selected as the control group. Tumor tissue samples were obtained and the expression level and phenotypes of the TIDCs were analyzed. The correlation between TIDC expression and clinical characteristics of patients with esophageal cancer was investigated. RESULTS: The density of the TIDCs in the observation group was lower than that in the control group (8.76±2.25 vs. 9.97±2.19; P=0.000). Furthermore, the percentage of major histocompatibility complex-II (MHC-II) positive DCs and the percentage of CD54 positive DCs were relatively lower in the observation group compared to the control group (6.60%±2.12% vs. 9.34%±2.41%; P=0.000 and 7.41%±2.36% vs. 9.98%±2.47%; P=0.000, respectively). Esophageal cancer patients with lymph node metastasis had lower TIDC density, lower percentage of MHC-II positive DCs, and lower percentage of CD54 positive DCs compared to patients without node metastasis (P |
| Databáze: | OpenAIRE |
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