Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control
| Autor: | Nikolaus Kleindienst, Charlotte Kreutz, Jana Müller, Markus Weiler, Maximilian Koeppel, Joachim Wiskemann, Georges Sam, Steffen Ringhof, Andreas Schneeweiss |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_treatment Science Sensory system Antineoplastic Agents Comorbidity Somatosensory system Article 03 medical and health sciences 0302 clinical medicine Neoplasms Antineoplastic Combined Chemotherapy Protocols Medicine Humans Longitudinal Studies Signs and symptoms Postural Balance Aged Chemotherapy Multidisciplinary business.industry Snap Cancer Peripheral Nervous System Diseases Middle Aged medicine.disease Peripheral neuropathy Chemotherapy-induced peripheral neuropathy Neurology Oncology Risk factors 030220 oncology & carcinogenesis Anesthesia Female Disease Susceptibility Symptom Assessment business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Impaired postural control is often observed in response to neurotoxic chemotherapy. However, potential explanatory factors other than chemotherapy-induced peripheral neuropathy (CIPN) have not been adequately considered to date due to primarily cross-sectional study designs. Our objective was to comprehensively analyze postural control during and after neurotoxic chemotherapy, and to identify potential CIPN-independent predictors for its impairment. Postural control and CIPN symptoms (EORTC QLQ-CIPN20) were longitudinally assessed before, during and three weeks after neurotoxic chemotherapy, and in three and six months follow-up examinations (N = 54). The influence of peripheral nerve function as determined by nerve conduction studies (NCS: compound motor action potentials (CMAP) and sensory action potentials (SNAP)), physical activity, and muscle strength on the change in postural control during and after chemotherapy was analyzed by multiple linear regression adjusted for age and body mass index. Postural control, CIPN signs/symptoms, and CMAP/SNAP amplitudes significantly deteriorated during chemotherapy (p p p |
| Databáze: | OpenAIRE |
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