Computer Design of Low-Molecular-Weight Inhibitors of Coagulation Factors

Autor:	Elena N. Lipets, Elena I. Sinauridze, Fazoil I. Ataullakhanov, A S Kabankin
Rok vydání:	2019
Předmět:	Computer design medicine.drug_class business.industry Anticoagulant Anticoagulants General Medicine Pharmacology Biochemistry Blood Coagulation Factors Molecular Weight Clinical trial Coagulation medicine Computer-Aided Design Humans business
Zdroj:	Biochemistry (Moscow). 84:119-136
ISSN:	1608-3040 0006-2979
DOI:	10.1134/s0006297919020032
Popis:	The review discusses main approaches to searching for new low-molecular-weight inhibitors of coagulation factors IIa, Xa, IXa, and XIa and the results of such studies conducted from 2015 to 2018. For each of these factors, several inhibitors with IC50 < 10 nM have been found, some of which are now tested in clinical trials. However, none of the identified inhibitors meets the requirements for an "ideal" anticoagulant, so further studies are required.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ffe4d5b5f55e8db8e34d6104aa267d https://doi.org/10.1134/s0006297919020032 Zobrazit plný text záznamu Plný text ve formátu PDF