Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents

Autor:	Yizhen Yu, Yanmei Zhang, Xiaozhou Ye, Qiuge Yan, Jie Tang, Chunxia Wu, Yuqiao Ma, Hongjuan Chang, Juan Huang, Lina Tang, Linguo Wu
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Adolescent Genotyping Techniques media_common.quotation_subject Science Single-nucleotide polymorphism Polymorphism Single Nucleotide Article 03 medical and health sciences 0302 clinical medicine Asian People Sirtuin 1 Genotype Juvenile delinquency Medicine Personality Humans Antisocial personality Genetic Predisposition to Disease Association (psychology) Genetic association media_common Genetics Multidisciplinary business.industry Haplotype Antisocial Personality Disorder 030227 psychiatry Haplotypes business 030217 neurology & neurosurgery
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) Scientific Reports
ISSN:	2045-2322
Popis:	Accumulating evidence suggests an association between the SIRT1 gene and human psychiatric disorders. The aim of the study was to investigate the association between SIRT1 and predisposition to antisocial personality traits (ASP) in Chinese adolescents. Participants consisted of 327 controls and 261 juvenile offenders who were diagnosed with predisposition to ASP according to the Personality Diagnostic Questionnaire. Four tag single nucleotide polymorphisms (tagSNPs) of SIRT1, namely rs12778366, rs7896005, rs10823112, and rs4746720, were genotyped. Association analysis between individual SNPs and ASP risk revealed the CC genotype of rs4746720 to be significantly associated with reduced risk of ASP (OR = 0.51, 95% CI = 0.33–0.77, adjusted P = 0.007). Haplotype analysis showed the TAAC haplotype was associated with reduced susceptibility to ASP (OR = 0.72, 95% CI = 0.57–0.91, P = 0.005). Moreover, rs4746720 variants were found to not only have a direct impact on ASP susceptibility but also modulate the effect of alcohol consumption (Y = 0.022X + 0.431 vs. Y = −0.066X + 0.387). The present study is the first to report a significant association between SIRT1 polymorphisms and ASP in adolescents. This finding is expected to aid in the development of effective interventions for this socially and personally costly disorder.
Databáze:	OpenAIRE
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