Synthesis of histidine kinase inhibitors and their biological properties
| Autor: | Patrick Meffre, Zohra Benfodda, Hendrik Szurmant, Miyanou Rosales-Hurtado |
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| Rok vydání: | 2019 |
| Předmět: |
Histidine Kinase
medicine.drug_class Antibiotics Virulence Models Biological Article 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Biological property Drug Discovery medicine Animals Humans Protein Kinase Inhibitors 030304 developmental biology Pharmacology 0303 health sciences biology Chemistry Histidine kinase Salicylanilides biology.organism_classification Biochemistry 030220 oncology & carcinogenesis Molecular Medicine Signal transduction Goals Bacteria |
| Zdroj: | Med Res Rev |
| ISSN: | 1098-1128 0198-6325 |
| Popis: | Infections caused by multidrug-resistant bacteria represent a significant and ever-increasing cause of morbidity and mortality. There is thus an urgent need to develop efficient and well-tolerated antibacterials targeting unique cellular processes. Numerous studies have led to the identification of new biological targets to fight bacterial resistance. Two-component signal transduction systems are widely employed by bacteria to translate external and cellular signals into a cellular response. They are ubiquitous in bacteria, absent in the animal kingdom and are integrated into various virulence pathways. Several chemical series, including isothiazolidones, imidazolium salts, benzoxazines, salicylanilides, thiophenes, thiazolidiones, benzimidazoles and other derivatives deduced by different approaches have been reported in the literature to have histidine kinase inhibitory activity. In this review, we report on the design and the synthesis of these histidine kinases inhibitors and their potential to serve as antibacterial agents. |
| Databáze: | OpenAIRE |
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