Pyridostigmine restores cardiac autonomic balance after small myocardial infarction in mice

Autor: Christiane Becari, Carlos Alberto Aguiar Silva, Marina T. Durand, Rubens Fazan, Mauro de Oliveira, Cibele M. Prado, Helio Cesar Salgado, Jussara M. do Carmo
Rok vydání: 2013
Předmět:
Cardiac function curve
Tachycardia
Male
Cardiotonic Agents
Physiology
Drug Evaluation
Preclinical
Myocardial Infarction
Cardiology
lcsh:Medicine
Hemodynamics
Blood Pressure
Infusions
Subcutaneous
Autonomic Nervous System
Cardiovascular Physiology
Nervous System
Ventricular Function
Left
Cardiovascular Pharmacology
Heart rate
Medicine and Health Sciences
Medicine
Animals
Myocardial infarction
Vagal tone
lcsh:Science
Heart Failure
Multidisciplinary
business.industry
Myocardium
Acute Cardiovascular Problems
lcsh:R
Biology and Life Sciences
medicine.disease
Mice
Inbred C57BL
Blood pressure
Neurology
Heart failure
Anesthesia
Blood Circulation
Cardiovascular Anatomy
lcsh:Q
INFARTO DO MIOCÁRDIO (FISIOPATOLOGIA)
Cholinesterase Inhibitors
medicine.symptom
Anatomy
business
Pyridostigmine Bromide
Research Article
Nervous System Physiology
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e104476 (2014)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1932-6203
Popis: The effect of pyridostigmine (PYR) - an acetylcholinesterase inhibitor - on hemodynamics and cardiac autonomic control, was never studied in conscious myocardial infarcted mice. Telemetry transmitters were implanted into the carotid artery under isoflurane anesthesia. Seven to ten days after recovery from the surgery, basal arterial pressure and heart rate were recorded, while parasympathetic and sympathetic tone (ΔHR) was evaluated by means of methyl atropine and propranolol. After the basal hemodynamic recording the mice were subjected to left coronary artery ligation for producing myocardial infarction (MI), or sham operation, and implantation of minipumps filled with PYR or saline. Separate groups of anesthetized (isoflurane) mice previously (4 weeks) subjected to MI, or sham coronary artery ligation, were submitted to cardiac function examination. The mice exhibited an infarct length of approximately 12%, no change in arterial pressure and increased heart rate only in the 1st week after MI. Vagal tone decreased in the 1st week, while the sympathetic tone was increased in the 1st and 4th week after MI. PYR prevented the increase in heart rate but did not affect the arterial pressure. Moreover, PYR prevented the increase in sympathetic tone throughout the 4 weeks. Concerning the parasympathetic tone, PYR not only impaired its attenuation in the 1st week, but enhanced it in the 4th week. MI decreased ejection fraction and increased diastolic and systolic volume. Therefore, the pharmacological increase of peripheral acetylcholine availability by means of PYR prevented tachycardia, increased parasympathetic and decreased sympathetic tone after MI in mice.
Databáze: OpenAIRE
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