The Parathyroid Gland and Heart Disease
| Autor: | Mary D. Ruppe, Spandana Brown, Laila Tabatabai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Heart disease Heart Diseases Parathyroid Diseases Parathyroid hormone 030204 cardiovascular system & hematology Risk Assessment Parathyroid Glands 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Calcium metabolism Hyperparathyroidism business.industry Heart General Medicine Articles medicine.disease Prognosis Endocrinology medicine.anatomical_structure Hypoparathyroidism Heart failure Parathyroid disorder Parathyroid gland business hormones hormone substitutes and hormone antagonists |
| Popis: | The parathyroid glands are critical to maintaining calcium homeostasis through actions of parathyroid hormone (PTH). Recent clinical and molecular research has shown that direct and indirect actions of PTH also affect the heart and vasculature through downstream actions of G protein-coupled receptors in the myocardium and endothelial cells. Patients with disorders of the parathyroid gland have higher incidences of hypertension, arrhythmias, left ventricular hypertrophy, heart failure, and calcific disease which translate into increased cardiac morbidity and mortality. Importantly, clinical research also suggests that early treatment of parathyroid disorders through medical or surgical management may reverse cardiovascular remodeling and mitigate cardiac risk factors. |
| Databáze: | OpenAIRE |
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