Strong Cellular Immune Response, but Not Humoral, against SARS-CoV-2 in Oncohematological Patients with Autologous Stem Cell Transplantation after Natural Infection
| Autor: | Vigon-Hernandez, Lorena, Sánchez-Tornero, Adrián, Rodríguez-Mora, Sara, Garcia-Perez, Javier, Corona de Lapuerta, Magdalena, Pérez-Lamas, Lucía, Casado-Fernández, Guiomar, Moreno, Gemma, Torres, Montserrat, Mateos, Elena, Murciano-Antón, María Aránzazu, Alcamí, José, Perez-Olmeda, Mayte, López-Jiménez, Javier, García-Gutiérrez, Valentín, Coiras, Mayte, Multidisciplinary Group Of Study Of Covid-Mgs-Covid, Casado-Fernández |
|---|---|
| Přispěvatelé: | Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), National Institutes of Health (Estados Unidos) |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) Journal of Clinical Medicine; Volume 11; Issue 8; Pages: 2137 |
| Popis: | Oncohematological patients show a low immune response against SARS-CoV-2, both to natural infection and after vaccination. Most studies are focused on the analysis of the humoral response; therefore, the information available about the cellular immune response is limited. In this study, we analyzed the humoral and cellular immune responses in nine individuals who received chemotherapy for their oncohematological diseases, as well as consolidation with autologous stem cell transplantation (ASCT), after being naturally infected with SARS-CoV-2. All individuals had asymptomatic or mild COVID-19 and were not vaccinated against SARS-CoV-2. These results were compared with matched healthy individuals who also had mild COVID-19. The humoral response against SARS-CoV-2 was not detected in 6 of 9 oncohematological individuals prior to ASCT. The levels of antibodies and their neutralization capacity decreased after ASCT. Conversely, an enhanced cytotoxic activity against SARS-CoV-2-infected cells was observed after chemotherapy plus ASCT, mostly based on high levels of NK, NKT, and CD8+TCRγδ+ cell populations that were able to produce IFNγ and TNFα. These results highlight the importance of performing analyses not only to evaluate the levels of IgGs against SARS-CoV-2, but also to determine the quality of the cellular immune response developed during the immune reconstitution after ASCT. This work was supported by the Coordinated Research Activities at the Centro Nacional de Microbiología (CNM, Instituto de Salud Carlos III) (COV20_00679) to promote an integrated response against SARS-CoV-2 in Spain (Spanish Ministry of Science and Innovation) that is coordinated by Dr Inmaculada Casas (WHO National Influenza Center of the CNM), the Spanish Ministry of Science and Innovation (PID2019-110275RB-I00), and AES 2021 grant from Instituto de Salud Carlos III (PI21/00877). The work of Sara Rodríguez-Mora is financed by NIH grant R01AI143567. The work of Montserrat Torres is supported by Instituto de Salud Carlos III (COV20_00679). The work of Lorena Vigón is supported by a pre-doctoral grant from Instituto de Salud Carlos III (FIS PI16CIII/00034-ISCIII-FEDER). Sí |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|