Differentiation of functional gastrointestinal disorders from healthy volunteers by lactulose hydrogen breath test and test meal
| Autor: | Simon Bütikofer, Fritz Murray, Michael Fried, Larissa Schnurre, Valeria Schindler, Daniel Runggaldier, Daniel Pohl, Stéphanie Giezendanner, Annina Zweig |
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| Přispěvatelé: | University of Zurich, Schindler, Valeria |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Abdominal pain Adolescent Nausea 610 Medicine & health 10045 Clinic for Otorhinolaryngology Gastroenterology Diagnosis Differential Irritable Bowel Syndrome 03 medical and health sciences Lactulose Young Adult 0302 clinical medicine Internal medicine medicine Humans 2715 Gastroenterology Prospective Studies Dyspepsia Irritable bowel syndrome Aged medicine.diagnostic_test Hepatology business.industry Odds ratio Middle Aged medicine.disease Postprandial Period Confidence interval 3. Good health Postprandial 10219 Clinic for Gastroenterology and Hepatology Breath Tests 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology 2721 Hepatology Female medicine.symptom business Hydrogen breath test Biomarkers medicine.drug Hydrogen |
| Zdroj: | Journal of gastroenterology and hepatology. 34(5) |
| ISSN: | 1440-1746 |
| Popis: | Background and aim Functional dyspepsia (FD) is a common disorder of gut-brain interaction with incompletely understood pathophysiology. Consequently, heterogeneous expert opinions on diagnostic tests and assessment of treatment efficacies exist. So far, no consensus about the most relevant diagnostic and outcome tool has been reached. In this study, we aimed to analyze the significance of a combined lactulose hydrogen breath test (LHBT) and liquid meal, yet representing a standardized test in irritable bowel syndrome (IBS), in FD. Methods We analyzed data of 146 FD, 204 IBS patients, and 50 healthy volunteers (HV). All patients underwent LHBT with a meal-drink consisting of 30-g Lactulose and 400-mL Ensure®. Effect of abdominal symptom generation in FD/IBS compared with HV was assessed on a patient-reported Likert-scale. Results There was a significant difference between FD/IBS patients and HV in LHBT-induced abdominal pain (odds ratio [OR] 246.9, 95% confidence interval [CI] 26.6-2290.7; OR 161.2, 95% CI 16.9-1534.8), abdominal bloating (OR 384.8, 95% CI 92.9-2135.4; OR 524.1, 95% CI 114.7-3432.3), borborygmi (OR 9.9, 95% CI 2.2-46.9; OR 17.7, 95% CI 4.7-67.4), nausea only in FD (OR 174.4, 95% CI 15.5-5375.5), and diarrhea in IBS only (OR 25.8, 95% CI 2.0-7012.6). Hydrogen production was not significantly different in FD/IBS and HV. Conclusions In this study, we demonstrated significant differences in postprandial symptom generation in FD and IBS compared with HV after LHBT. This does not only allow us to discriminate FD/IBS from HV but may also represent a diagnostic and monitoring tool for FD/IBS in the future, including monitoring of treatment effects. |
| Databáze: | OpenAIRE |
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