MTHFRC677T and A1298C Polymorphisms Were Associated with Bladder Cancer Risk and Disease Progression: A Meta-Analysis
| Autor: | Li Weng-Guang, Zhang Yu-Ping, Wu You, Xing Qian-Wei, Li Hua-Lei, Chen Jing, Zuo Li |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Threonine
Oncology medicine.medical_specialty Population Polymorphism Single Nucleotide Risk Factors Internal medicine Epidemiology Genetics medicine Humans Mthfr c677t Genetic Predisposition to Disease Cysteine education Molecular Biology Methylenetetrahydrofolate Reductase (NADPH2) education.field_of_study Alanine Bladder cancer biology Carcinoma Cell Biology General Medicine Odds ratio medicine.disease digestive system diseases Confidence interval Amino Acid Substitution Urinary Bladder Neoplasms Case-Control Studies Methylenetetrahydrofolate reductase Meta-analysis Disease Progression biology.protein Polymorphism Restriction Fragment Length |
| Zdroj: | DNA and Cell Biology. 32:260-267 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2012.1931 |
| Popis: | Epidemiological studies have investigated that functional polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene may play an essential role in bladder carcinogenesis, but the association between these single-nucleotide polymorphisms in the MTHFR gene and the susceptibility of bladder cancer (BC) was inconsistent in previous studies. The objective of this current study was to conduct an update analysis investigating the association between three polymorphisms in the MTHFR gene and the risk of BC. We performed a meta-analysis of 13 publications involving an association between BC and MTHFR gene three polymorphisms (C677T, A1298C, and G1793A). We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). On one hand, we found that the C677T polymorphism was associated with increased BC risk among Asians, however, with decreased BC risk among a mixed population. Interestingly, BC patients who carried the T-allele (TT+TC) had a higher percentage than the individuals who carried the CC genotype (OR=1.38, 95% CI=1.13-1.69, p=0.002). On the other hand, the A1298C polymorphism may increase BC risk among Asians and Africans, but played a decreased association among Europeans. Results from the current update analysis suggested that the C677T and A1298C polymorphisms in the MTHFR gene were associated with BC risk and disease progression. |
| Databáze: | OpenAIRE |
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