Matrix tablets based on a carrageenan with the modified-release of sodium riboflavin 5′-phosphate
| Autor: | Klára Pintye-Hódi, András Kelemen, Tamás Sovány, Gyula Buchholcz |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Flavin Mononucleotide
Sodium Pharmaceutical Science chemistry.chemical_element Lactose Riboflavin Carrageenan Matrix (chemical analysis) chemistry.chemical_compound Humans Cellulose Dissolution Active ingredient Chromatography Chemistry food and beverages General Medicine Factorial experiment Hydrogen-Ion Concentration Microcrystalline cellulose Drug Liberation Solubility Delayed-Action Preparations Vitamin B Complex Tablets |
| Zdroj: | Pharmaceutical Development and Technology. 20:676-683 |
| ISSN: | 1097-9867 1083-7450 |
| DOI: | 10.3109/10837450.2014.910810 |
| Popis: | The focus of this work was to produce modified-release monolithic matrix tablets containing sodium riboflavin 5'-phosphate (vitamin B2) as active pharmaceutical ingredient (API). Riboflavin 5'-phosphate is absorbed from the upper gastrointestinal tract by a specific transport mechanism. The aim of this work was the development of modified-release tablets from which most or the entire API can dissolve within 5 h. The dissolution was started in medium pH 1.2 (gastric juice) and finished in medium pH 4.5. The matrix former was iota-carrageenan combined with microcrystalline cellulose (MCC) and lactose in different ratios. Factorial design was used in this work so as to study the effects of the MCC/lactose ratio on the parameters of the tablets, and especially on the dissolution process. The dissolution data were subjected to statistical analysis, and the release profiles were fitted with different models. It was found that the MCC/lactose ratio influenced the quality of the tablets to a high degree. The Korsmeyer-Peppas model proved to characterize the total dissolution profile best, but fitting of the separate sections was also possible with a linear model. |
| Databáze: | OpenAIRE |
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