[18F]FDG and [18F]NaF as PET markers of systemic atherosclerosis progression: A longitudinal descriptive imaging study in patients with type 2 diabetes mellitus

Autor: Douwe J. Mulder, Robert A. Pol, C A Te Velde-Keyzer, Melanie Reijrink, J K E Sluiter, Hiddo J.L. Heerspink, Marcel J. W. Greuter, Riemer H. J. A. Slart, S A de Boer, J.L. Hillebrands
Přispěvatelé: Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Translational Immunology Groningen (TRIGR), Cardiovascular Centre (CVC)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Nuclear Cardiology. SPRINGER
ISSN: 1071-3581
Popis: Background While [18F]-fluordeoxyglucose ([18F]FDG) uptake is associated with arterial inflammation, [18F]-sodium fluoride ([18F]NaF) is a marker for arterial micro-calcification. We aimed to investigate the prospective correlation between both PET markers over time and whether they are prospectively ([18F]FDG) and retrospectively ([18F]NaF) related to progression of systemic arterial disease in a longitudinal study in patients with type 2 diabetes mellitus (T2DM). Methods Baseline [18F]FDG PET/Low Dose (LD) Computed Tomography (CT) scans of ten patients with early T2DM without cardiovascular history (70% men, median age 63 years) were compared with five-year follow-up [18F]NaF/LDCT scans. Systemic activity was expressed as mean target-to-background ratio (meanTBR) by dividing the maximal standardized uptake value (SUVmax) of ten arteries by SUVmean of the caval vein. CT-assessed macro-calcifications were scored visually and expressed as calcified plaque (CP) score. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (PWV). Five-year changes were expressed absolutely with delta (Δ) and relatively with %change. Results Baseline meanTBR[18F]FDG was strongly correlated with five-year follow-up meanTBR[18F]NaF (r = 0.709, P = .022). meanTBR[18F]NaF correlated positively with ΔCPscore, CPscore at baseline, and follow-up (r = 0.845, P = .002 and r = 0.855, P = .002, respectively), but not with %change in CPscore and PWV. Conclusion This proof-of-concept study demonstrated that systemic arterial inflammation is an important pathogenetic factor in systemic arterial micro-calcification development.
Databáze: OpenAIRE
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