Dermatofibrosarcoma Protuberans with EMA+ Cells. Report of a Case Suggesting Perineurial Cell Differentiation
| Autor: | Petr Mukensnabl, Michal Michal, Ludek Baumruk, Michal Zamecnik |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Skin Neoplasms Cellular differentiation CD34 Biology Groin Perineurial Cell Pathology and Forensic Medicine Perineural Cell Perineurioma medicine Dermatofibrosarcoma protuberans Humans Peripheral Nerves Dermatofibrosarcoma Mucin-1 Cell Differentiation Cell Biology medicine.disease Immunohistochemistry External lamina Microscopy Electron Female |
| Zdroj: | Pathology - Research and Practice. 198:767-774 |
| ISSN: | 0344-0338 |
| DOI: | 10.1078/0344-0338-00334 |
| Popis: | A case of dermatofibrosarcoma protuberans (DFSP) with epithelial membrane antigen (EMA)-positive cells is described. The tumor was excised from the left groin of a 28-year-old woman. It showed characteristic histologic features of DFSP with typical diffuse immunohistochemical positivity for CD34. Moreover, scattered neoplastic cells expressed EMA, suggesting perineural cell differentiation. Ultrastructural study found perineurial cell features, such as thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions. This observation, together with previous immunohistochemical findings of EMA-positive cells in a subset of DFSPs, strongly suggests perineurial cell differentiation in these tumors. DFSP should be included in the differential diagnosis of EMA-positive spindle cell lesions of superficial soft tissue and skin. |
| Databáze: | OpenAIRE |
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