Neuropathology and brain weight in traumatic-crush asphyxia
| Autor: | Nat R.B. Cary, Safa Al-Sarraj, Ben Swift, Rob C. Chapman, Ashley W. Fegan-Earl, Ross Laxton, Alexander J. Kolar |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Traumatic asphyxia Thoracic Injuries Body height Neuropathology Pathology and Forensic Medicine Brain Ischemia 03 medical and health sciences Amyloid beta-Protein Precursor Asphyxia Crush Injuries Young Adult 0302 clinical medicine Medicine Humans 030216 legal & forensic medicine Forensic Pathology Aged Aged 80 and over business.industry Brain General Medicine Organ Size Middle Aged medicine.disease Trunk Anesthesia Cohort Female medicine.symptom business Brain examination Brain weight Law Intracranial Hemorrhages 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of forensic and legal medicine. 52 |
| ISSN: | 1878-7487 |
| Popis: | Traumatic (crush) asphyxia is a rare condition caused by severe compression of the chest and trunk leading to often extreme so-called asphyxial signs, including cyanosis in head and neck regions, multiple petechiae, and subconjunctival haemorrhage as well as neurological manifestations. Aims To investigate the neuropathology and brain weight in traumatic asphyxia caused by different accidents such as industrial accidents and road traffic collision. Material and Methods Post mortem records of 20 cases of traumatic asphyxia (TA) resulting from different causes of which four brains are available for comprehensive neuropathological examination. The expected brain weights for given body height and associated 95% confidence range were calculated according to the following formula: baseline brain weight (BBW) + body height x rate (g/cm). The 95% confidence range was calculated by adding and subtracting the standard error (SE) x 1.96 (7–8). Results There was a trend for higher brain weight in the TA cohort but it was not significant (1494 g vs 1404 g, p = 0.1). The upper limits of the brain weight of 95% confidence was 1680 g vs 1660 g, p = 0.9. The neuropathological examination of four available brains from the TA cohort showed severe congestion of blood vessels, perivascular haemorrhages and occasional βAPP deposits consistent with early axonal disruption. Conclusion Brain examination is informative as part of investigation of TA. Developing ischaemic changes and an increase in brain weight are the most likely indicators of a prolonged period of patient's survival. |
| Databáze: | OpenAIRE |
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