Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice
| Autor: | Marco Novelli, Malgorzata S. Martin-Gronert, Paul D. Taylor, Susan E. Ozanne, Denise S. Fernandez-Twinn, Chad McKee, Anne-Maj Samuelsson, J Soeda, Barbara Sigala, Phillippa Matthews, Jude A. Oben, A Mouralidarane, Lucilla Poston, Maelle Morgan |
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| Rok vydání: | 2010 |
| Předmět: |
Leptin
medicine.medical_specialty Offspring media_common.quotation_subject Gene Expression Adipose tissue Biology Collagen Type I Mice Insulin resistance Pregnancy Receptors Adrenergic alpha-1 Internal medicine medicine Animals Lactation Obesity media_common Metabolic Syndrome Hepatology Interleukin-6 Tumor Necrosis Factor-alpha Fatty liver nutritional and metabolic diseases Appetite medicine.disease Actins Fatty Liver Mice Inbred C57BL Pregnancy Complications Milk Endocrinology Adipose Tissue Prenatal Exposure Delayed Effects Female Collagen Steatohepatitis Signal Transduction |
| Zdroj: | Journal of Hepatology. 52:913-920 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/j.jhep.2009.12.042 |
| Popis: | Background & aims Obesity induced, non-alcoholic fatty liver disease (NAFLD), is now the major cause in affluent countries, of the spectrum of steatosis-to-cirrhosis. Obesity and NAFLD rates in reproductive age women, and adolescents, are rising worldwide. Our hypothesis was that maternal obesity and lactation transmit to the offspring a pre-disposition to dysmetabolism, obesity and NAFLD. Methods Female mice were fed standard or obesogenic chow, before, throughout pregnancy, and during lactation. The critical developmental period was studied by cross-fostering offspring of lean and obese dams. Offspring were then weaned onto standard chow and studied at 3months. Read-outs included markers of metabolic dysfunction, biochemical and histological indicators of NAFLD, induction of liver fibrogenesis, and activation of pro-fibrotic pathways. Mechanisms involved in programming a dysmetabolic and NAFLD phenotype were investigated by assaying breast milk components. Results Offspring of obese dams had a dysmetabolic, insulin resistant and NAFLD phenotype compared to offspring of lean dams. Offspring of lean dams that were suckled by obese dams showed an exaggerated dysmetabolic and NAFLD phenotype, with increased body weight, as well as increased levels of insulin, leptin, aspartate transaminase, interleukin-6, tumour necrosis factor-alpha, liver triglycerides, steatosis, hepatic fibrogenesis, renal norepinephrine, and liver alpha1-D plus beta1-adrenoceptors, indicative of sympathetic nervous system activation. Obese dams also had raised breast milk leptin levels compared to lean dams. Conclusions Maternal obesity programs development of a dysmetabolic and NAFLD phenotype, which is critically dependent on the early postnatal period and possibly involving alteration of hypothalamic appetite nuclei signalling by maternal breast milk and neonatal adipose tissue derived, leptin. |
| Databáze: | OpenAIRE |
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