Acute monoarthritis in young children: comparing the characteristics of patients with juvenile idiopathic arthritis versus septic and undifferentiated arthritis
| Autor: | Albert Faye, Cindy Mallet, Mathie Lorrot, Stéphane Bonacorsi, Marion Thomas, Marion Caseris, Glory Dingulu, Camille Aupiais, Ulrich Meinzer, Ivo G. Boneca, Anne-Laure Simon |
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| Přispěvatelé: | Hôpital Robert Debré Paris, Hôpital Robert Debré, Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), his study was supported by a grant of then French National Research Agency (GUT-JIA ANR-16-CE17-0009) to UM, a grant of the Clinical Research and Innovation Department of Assistance Publique—Hôpitaux de Paris (CRC TDR-Arthrite) to UM and a grant from the French Society for Rheumatology (SFR) to MT., ANR-16-CE17-0009,GUT-JIA,Etude translationnelle du rôle de la barrière intestinale et du microbiote dans la physiopathologie de l'arthrite juvénile idiopathique.(2016), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Gestionnaire, Hal Sorbonne Université, Etude translationnelle du rôle de la barrière intestinale et du microbiote dans la physiopathologie de l'arthrite juvénile idiopathique. - - GUT-JIA2016 - ANR-16-CE17-0009 - AAPG2016 - VALID |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Acute arthritis genetic structures Neisseriaceae Infections [SDV]Life Sciences [q-bio] Antibiotics Arthritis Kingella kingae 0302 clinical medicine immune system diseases Medicine Child skin and connective tissue diseases Multidisciplinary biology Oligoarticular JIA Anti-Bacterial Agents 3. Good health [SDV] Life Sciences [q-bio] Undifferentiated arthritis Child Preschool Administration Intravenous Female France musculoskeletal diseases medicine.medical_specialty medicine.drug_class Science Article 03 medical and health sciences Medical research Rheumatology 030225 pediatrics Internal medicine Monoarthritis Humans Synovial fluid 030203 arthritis & rheumatology Arthritis Infectious business.industry Infant medicine.disease biology.organism_classification Arthritis Juvenile business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.3422. ⟨10.1038/s41598-021-82553-1⟩ Scientific Reports, 2021, 11 (1), pp.3422. ⟨10.1038/s41598-021-82553-1⟩ Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Acute arthritis is a common cause of consultation in pediatric emergency wards. Arthritis can be caused by juvenile idiopathic arthritis (JIA), septic (SA) or remain undetermined (UA). In young children, SA is mainly caused by Kingella kingae (KK), a hard to grow bacteria leading generally to a mild clinical and biological form of SA. An early accurate diagnosis between KK-SA and early-onset JIA is essential to provide appropriate treatment and follow-up. The aim of this work was to compare clinical and biological characteristics, length of hospital stays, duration of intravenous (IV) antibiotics exposure and use of invasive surgical management of patients under 6 years of age hospitalized for acute monoarthritis with a final diagnosis of JIA, SA or UA. We retrospectively analyzed data from 9/L [10–13.6]) when compared to SA (13.2 × 109/L [11–16.6]), p = 0.01. In synovial fluid leucocytes were higher in SA 105.5 × 103 cells/mm3 [46–211] compared to JIA and UA (42 × 103 cells/mm3 [6.4–59.2] and 7.29 × 103 cells/mm3 [2.1–72] respectively), p Kingellakingae in these patients. |
| Databáze: | OpenAIRE |
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