Prevention of Atopic Dermatitis in Mice by Lactobacillus Reuteri Fn041 Through Induction of Regulatory T Cells and Modulation of the Gut Microbiota
| Autor: | Jingbo Zhou, Yuning Zhao, Jin Sun, Renqiang Yu, Mengyao Lu, Shuangqi Li, Duo Li, Jie Chen, Hongyang Dang, Haowen Zhang, Xinyue Li, Ce Qi |
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| Rok vydání: | 2022 |
| Předmět: |
Limosilactobacillus reuteri
Regulatory T cell Gut flora Breast milk T-Lymphocytes Regulatory Dermatitis Atopic Mice fluids and secretions Immune system Pregnancy Lactobacillus medicine Animals Humans Mice Inbred BALB C Bacteria Milk Human biology food and beverages FOXP3 Akkermansia biology.organism_classification Gastrointestinal Microbiome Lactobacillus reuteri medicine.anatomical_structure Immunoglobulin A Secretory Immunology Female Food Science Biotechnology |
| Zdroj: | Molecular Nutrition & Food Research. 66:2100699 |
| ISSN: | 1613-4133 1613-4125 |
| DOI: | 10.1002/mnfr.202100699 |
| Popis: | Scope The development of atopic dermatitis (AD) in infants is closely related to the lagging development of intestinal microbiota, including that inoculated by breast milk bacteria, and immune development. Lactobacillus reuteri Fn041 is a secretory immunoglobulin A (sIgA) -coated bacterium derived from human milk. Methods and results We intervened with L. reuteri Fn041 in maternal and offspring BALB/C mice during late gestation and lactation and after weaning of the pups, respectively. AD was then induced with MC903. L. reuteri Fn041 significantly suppressed AD symptoms such as skin swelling, mast cell and eosinophil infiltration. This effect was attributed to the regulation of the systemic Th1 and Th2 cytokine ratios and the promotion of CD4+ CD25+ Foxp3+ regulatory T cell proliferation in mesenteric lymph nodes. It is also associated with the regulation of intestinal microbiota, particularly promoting Lactobacillus and Akkermansia. Conclusions Our study strengthens the understanding that breast milk-derived sIgA coated potential probiotics are involved in the development of infant intestinal microbiota, thus promoting immune development and preventing allergic diseases, and expanding the knowledge of breast milk sIgA and bacterial interactions on infant immune development. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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